glycerolcholine phosphate

Base Information

• Chemical Name: glycerolcholine phosphate
• CAS No.: 34688-34-1
• Molecular Formula: C₈H₂₀NO₆P
• Molecular Weight: 257.224
• Mol file: 34688-34-1.mol

Synonyms:glycerolcholine phosphate

Chemical Property of glycerolcholine phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of glycerolcholine phosphate

There total 10 articles about glycerolcholine phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

phosphorylcholine chloride (107-73-3) + 3-monochloro-1,2-propanediol (96-24-2) → glycerolcholine phosphate (34688-34-1,563-24-6)

Guidance literature:

phosphorylcholine chloride; With potassium hydroxide; In ethanol; acetonitrile; at 80 ℃; for 0.5h;

3-monochloro-1,2-propanediol; In ethanol; acetonitrile; for 19h; Solvent; Temperature; Reflux;

Reference yield: 86.0%

(2R)-3-chloro-1,2-propanediol (57090-45-6) + phosphorylcholine chloride, calcium salt (4826-71-5) → glycerolcholine phosphate (34688-34-1,563-24-6)

Guidance literature:

phosphorylcholine chloride, calcium salt; With potassium oxalate; In water; at 20 ℃; for 2h;

(2R)-3-chloro-1,2-propanediol; With potassium hydroxide; In ethanol; for 6h;

Reference yield:

L-α-Dipalmitoylphosphatidylcholine (63-89-8) → glycerolcholine phosphate (34688-34-1,563-24-6) + 2-palmitoyl-sn-glycero-3-phosphorylcholine (6791-22-6,66757-27-5) + 1-palmitoyl-L-α-lysophosphatidylcholine (17364-16-8) + 1-hexadecylcarboxylic acid (57-10-3)

Guidance literature:

In water-d2; Product distribution; Ambient temperature; Irradiation; variation of exposure to radiation;

DOI:10.1002/mrc.1260300510

upstream raw materials:

choline-2,2-dimethyl-1,3-dioxolane-4-methyl phosphate

2-(2,2-dimethyl-1,3-dioxolan-4-ylmethoxy)-2-oxo-1,3,2-dioxaphospholane

trimethylamine

Phosphoric acid 2-chloro-ethyl ester 2-chloromethyl-4-nitro-phenyl ester (S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester

Downstream raw materials:

dimyristoylphosphatidylcholine

{2-[(2,3-bis-stearoyloxy-propoxy)-hydroxy-phosphoryloxy]-ethyl}-trimethyl-ammonium betaine

1-stearoyl-sn-glycero-3-phosphocholine

stearic acid

Refernces

• 1、 Wepy, James A.,Galligan, James J.,Kingsley, Philip J.,Xu, Shu,Goodman, Michael C.,Tallman, Keri A.,Rouzer, Carol A.,Marnett, Lawrence J.. "Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling". . p. 360 - 374. Retrieved 2019/02/19.
• 2、 -. "Method for Preparing Racemic or Optically Active α―Glycerophosphoryl choline". Paragraph 0091-0093. . Retrieved 2016/12/26.