α-phenylthio methyl pentanoate

Base Information

• Chemical Name: α-phenylthio methyl pentanoate
• CAS No.: 86895-65-0
• Molecular Formula: C₁₂H₁₆O₂S
• Molecular Weight: 224.324
• Mol file: 86895-65-0.mol

Synonyms:α-phenylthio methyl pentanoate

Chemical Property of α-phenylthio methyl pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-phenylthio methyl pentanoate

There total 4 articles about α-phenylthio methyl pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

methyl 2-bromovalerate (19129-92-1,114438-77-6,114438-78-7) + thiophenol (108-98-5) → α-phenylthio methyl pentanoate (86895-65-0)

Guidance literature:

With sodium hydroxide; In ethanol;

DOI:10.1016/S0040-4039(00)81858-4

Reference yield:

2-bromopentanoyl chloride (42768-45-6) → α-phenylthio methyl pentanoate (86895-65-0)

Guidance literature:

Multi-step reaction with 2 steps

2: 89 percent / NaOH / ethanol

With sodium hydroxide; In ethanol;

DOI:10.1016/S0040-4039(00)81858-4

Reference yield:

((Z)-1-Chloro-pent-1-enylsulfanyl)-benzene (83818-64-8) → α-phenylthio methyl pentanoate (86895-65-0)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine / CCl₄ / 0.67 h / -45 °C

2: aq. NaOH / 2 h / -45 °C

With sodium hydroxide; bromine; In tetrachloromethane;

upstream raw materials:

methyl 2-bromovalerate

thiophenol

((Z)-1-Chloro-pent-1-enylsulfanyl)-benzene

valeric acid

Downstream raw materials:

(E)-2-Phenylsulfanyl-pent-2-enoic acid methyl ester

(E)-methyl 2-methyl-2-phenylthiopent-3-enoate

methyl 2-benzoyl-4-phenylsulphinyloxypent-2-enoate

(E)-methyl 2-benzoyl-2-phenylthiopent-3-enoate

Refernces

• 1、 Durman, John,Grayson, J.Ian,Hunt, Paul G.,Warren, Stuart. "Synthesis of α-Phenylthio Enones and Esters of α-Phenylthio Alkenoic Acids". . p. 1939 - 1946. Retrieved 2007/10/02.
• 2、 Durman, John,Hunt, Paul G.,Warren, Stuart. "ALKYLATION OF EXTENDED ENOLATES FROM α-PHENYLTHIO CROTONATE ESTERS". . p. 2113 - 2116. Retrieved 2007/10/02.