2-(4-nitrophenyl)butanonitrile

Base Information

• Chemical Name: 2-(4-nitrophenyl)butanonitrile
• CAS No.: 94814-82-1
• Molecular Formula: C₁₀H₁₀N₂O₂
• Molecular Weight: 190.202
• Mol file: 94814-82-1.mol

Synonyms:2-(4-nitrophenyl)butanonitrile

Chemical Property of 2-(4-nitrophenyl)butanonitrile

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-nitrophenyl)butanonitrile

There total 5 articles about 2-(4-nitrophenyl)butanonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

4-Nitrophenylacetonitrile (555-21-5,34512-13-5,174848-08-9) + acetaldehyde (75-07-0,9002-91-9) → 2-(4-nitrophenyl)butanonitrile (94814-82-1)

Guidance literature:

With 2,6-dimethyl-3,5-diacetyl-1,4-dihydropyridine; L-proline; In dimethyl sulfoxide; at 25 ℃; for 24h;

DOI:10.1016/j.tetlet.2010.07.131

Reference yield:

2-phenylbutanenitrile (769-68-6) → 2-(4-nitrophenyl)butanonitrile (94814-82-1)

Guidance literature:

With sulfuric acid; nitric acid; at 0 - 5 ℃;

Reference yield:

methyl 2-cyano-2-(4-nitrophenyl)butyrate → 2-(4-nitrophenyl)butanonitrile (94814-82-1)

Guidance literature:

With water; potassium carbonate; In methanol; at 30 - 35 ℃; for 0.5h; Autoclave; Large scale;

DOI:10.1021/op9900075

upstream raw materials:

2-phenylbutanenitrile

4-Nitrophenylacetonitrile

acetaldehyde

4-chlorobenzonitrile

Downstream raw materials:

ethyl 4-cyano-4-(4-nitrophenyl)hexanoate

(+)₄₀₄-3-(4-aminophenyl)-3-ethyl-2,6-piperidinedione

(R)-(+)-3-ethyl-3-(4-nitrophenyl)piperidine-2,6-dione

2-(4-aminophenyl)butanoic acid

Refernces

• 1、 Bunegar, Michael J.,Dyer, Ulrich C.,Evans, Graham R.,Hewitt, Richard P.,Jones, Stephen W.,Henderson, Neil,Richards, Christopher J.,Sivaprasad, Sivadasan,Skead, Benjamin M.,Stark, Mark A.,Teale, Eric. "Production of (R)-aminoglutethimide: A new route from 1 -chloro-4-nitrobenzene". . p. 442 - 450. Retrieved 2013/09/08.