2-isocyano-succinic acid 4-benzyl ester N-methoxy-N-methylamide

Base Information

• Chemical Name: 2-isocyano-succinic acid 4-benzyl ester N-methoxy-N-methylamide
• CAS No.: 864510-39-4
• Molecular Formula: C₁₄H₁₆N₂O₄
• Molecular Weight: 276.292
• Mol file: 864510-39-4.mol

Synonyms:2-isocyano-succinic acid 4-benzyl ester N-methoxy-N-methylamide

Chemical Property of 2-isocyano-succinic acid 4-benzyl ester N-methoxy-N-methylamide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-isocyano-succinic acid 4-benzyl ester N-methoxy-N-methylamide

There total 4 articles about 2-isocyano-succinic acid 4-benzyl ester N-methoxy-N-methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

Nα-formyl-L-aspartic acid 4-benzyl ester N-methoxy-N-methylamide (864510-37-2) → 2-isocyano-succinic acid 4-benzyl ester N-methoxy-N-methylamide (864510-39-4)

Guidance literature:

N^α-formyl-L-aspartic acid 4-benzyl ester N-methoxy-N-methylamide; With triethylamine; trichlorophosphate; In dichloromethane; for 1h; cooling;

With potassium hydroxide; In dichloromethane; water; for 1h;

DOI:10.1081/SCC-200064913

Reference yield:

3-amino-N-methoxy-N-methyl-succinamic acid benzyl ester; compound with trifluoro-acetic acid → 2-isocyano-succinic acid 4-benzyl ester N-methoxy-N-methylamide (864510-39-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 2.85 g / N-methylmorpholine; N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide / CH₂Cl₂ / 0.25 h

2.1: triethylamine; POCl₃ / CH₂Cl₂ / 1 h / cooling

2.2: 83 percent / KOH / CH₂Cl₂; H₂O / 1 h

With 4-methyl-morpholine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trichlorophosphate; In dichloromethane;

DOI:10.1081/SCC-200064913

Reference yield:

BOC-L-aspartic acid 4-benzyl ester (7536-58-5,98482-77-0) → 2-isocyano-succinic acid 4-benzyl ester N-methoxy-N-methylamide (864510-39-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-methylmorpholine; isobutyl chloroformate / CH₂Cl₂ / 0.25 h / cooling

1.2: 94 percent / CH₂Cl₂ / 1 h

2.1: CH₂Cl₂ / 0.5 h

3.1: 2.85 g / N-methylmorpholine; N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide / CH₂Cl₂ / 0.25 h

4.1: triethylamine; POCl₃ / CH₂Cl₂ / 1 h / cooling

4.2: 83 percent / KOH / CH₂Cl₂; H₂O / 1 h

With 4-methyl-morpholine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trichlorophosphate; isobutyl chloroformate; In dichloromethane;

DOI:10.1081/SCC-200064913

upstream raw materials:

N^α-formyl-L-aspartic acid 4-benzyl ester N-methoxy-N-methylamide

BOC-L-aspartic acid 4-benzyl ester

N^α-(tert-butoxycarbonyl)-L-aspartic acid 4-benzyl ester N-methoxy-N-methylamide

Refernces