Glycine, N-[(dimethylamino)methylene]-, ethyl ester, [N(E)]- (9CI)

Base Information

• Chemical Name: Glycine, N-[(dimethylamino)methylene]-, ethyl ester, [N(E)]- (9CI)
• CAS No.: 428507-28-2
• Molecular Formula: C7H14 N2 O2
• Molecular Weight: 158.2
• Mol file: 428507-28-2.mol

Synonyms:(E)-(Dimethylaminomethyleneamino)aceticacid ethyl ester

Chemical Property of Glycine, N-[(dimethylamino)methylene]-, ethyl ester, [N(E)]- (9CI)

Chemical Property:

• PSA: 41.90000
• LogP: 0.13940

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Glycine, N-[(dimethylamino)methylene]-, ethyl ester, [N(E)]- (9CI)

There total 1 articles about Glycine, N-[(dimethylamino)methylene]-, ethyl ester, [N(E)]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

glycine ethyl ester hydrochloride (623-33-6) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → (E)-(dimethylamino-methyleneamino)-acetic acid ethyl ester (428507-28-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/S0040-4039(03)00078-9

Reference yield: 98.0%

(E)-(dimethylamino-methyleneamino)-acetic acid ethyl ester (428507-28-2) + 2-chloro-7-fluoro-4-methyl-3,4-dihydrobenzo[e][1,4]diazepin-5-one (193693-31-1) → flumazenil (78755-81-4)

Guidance literature:

(E)-(dimethylamino-methyleneamino)-acetic acid ethyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -35 ℃; for 1.5h;

2-chloro-7-fluoro-4-methyl-3,4-dihydrobenzo[e][1,4]diazepin-5-one; With Dimethyl-p-toluidine; In tetrahydrofuran; at -40 - -35 ℃; for 3h;

With acetic acid; In tetrahydrofuran; for 6h; pH=5 - 7; Heating;

DOI:10.1016/S0040-4039(03)00078-9

Reference yield: 82.0%

benzyl chloride (100-44-7) + (E)-(dimethylamino-methyleneamino)-acetic acid ethyl ester (428507-28-2) → 2-benzyl-2-(dimethylamino-methyleneamino)-3-phenyl-propionic acid ethyl ester

Guidance literature:

With lithium hexamethyldisilazane; at -30 ℃;

DOI:10.1016/S0040-4039(03)00078-9

upstream raw materials:

glycine ethyl ester hydrochloride

N,N-dimethyl-formamide dimethyl acetal

Downstream raw materials:

flumazenil

ethyl 5,6-dihydro-5-(2,4-dimethoxybenzyl)-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

Refernces