2-(benzyloxy)-6-nitro-2'-piperidinostyrene

Base Information

• Chemical Name: 2-(benzyloxy)-6-nitro-2'-piperidinostyrene
• CAS No.: 117609-04-8
• Molecular Formula: C₂₀H₂₂N₂O₃
• Molecular Weight: 338.406
• Mol file: 117609-04-8.mol

Synonyms:2-(benzyloxy)-6-nitro-2'-piperidinostyrene

Chemical Property of 2-(benzyloxy)-6-nitro-2'-piperidinostyrene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(benzyloxy)-6-nitro-2'-piperidinostyrene

There total 1 articles about 2-(benzyloxy)-6-nitro-2'-piperidinostyrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

tris(piperidino)-methane (22630-08-6) + 2-benzyloxy-6-nitrotoluene (20876-37-3) → 2-(benzyloxy)-6-nitro-2'-piperidinostyrene (117609-04-8)

Guidance literature:

at 110 ℃; for 6h;

DOI:10.1021/jo00372a037

Reference yield: 90.0%

2-(benzyloxy)-6-nitro-2'-piperidinostyrene (117609-04-8) → 4-benzyloxy-1H-indole (20289-26-3)

Guidance literature:

With nickel boride; hydrazine hydrate; In ethanol; Heating;

DOI:10.1021/jo00372a037

Reference yield:

2-(benzyloxy)-6-nitro-2'-piperidinostyrene (117609-04-8) → 1-<4-(benzyloxy)indol-3-yl>-2-aminopropane (2854-11-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / nickel boride, hydrazine hydrate / ethanol / Heating

2: 59 percent / benzene / Heating

3: 71 percent / nickel boride, hydrazine hydrate / propan-2-ol / 0.5 h / Heating

With nickel boride; hydrazine hydrate; In ethanol; isopropyl alcohol; benzene;

DOI:10.1021/jo00372a037

upstream raw materials:

tris(piperidino)-methane

2-benzyloxy-6-nitrotoluene

Downstream raw materials:

4-benzyloxy-1H-indole

1-<4-(benzyloxy)indol-3-yl>-2-aminopropane

1-<4-(benzyloxy)indol-3-yl>-2-nitropropane

Refernces

• 1、 Lloyd, David H.,Nichols, David E.. "A SIMPLE PROCEDURE FOR THE PREPARATION OF INDOLES". . p. 4561 - 4562. Retrieved 2007/10/02.