ETHYL4-METHYL-1H-IMIDAZOLE-2-CARBOXYLATE

Base Information

• Chemical Name: ETHYL4-METHYL-1H-IMIDAZOLE-2-CARBOXYLATE
• CAS No.: 40253-44-9
• Molecular Formula: C7H10 N2 O2
• Molecular Weight: 154.169
• Hs Code.: 2933290090
• Mol file: 40253-44-9.mol

Synonyms:1H-Imidazole-2-carboxylicacid, 4-methyl-, ethyl ester (9CI)

Chemical Property of ETHYL4-METHYL-1H-IMIDAZOLE-2-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0.00252mmHg at 25°C
• Refractive Index: 1.519
• Boiling Point: 287℃
• PKA: 11.81±0.10(Predicted)
• Flash Point: 128℃
• PSA: 54.98000
• Density: 1.171
• LogP: 0.89480
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl4-methyl-1H-imidazole-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL4-METHYL-1H-IMIDAZOLE-2-CARBOXYLATE

There total 7 articles about ETHYL4-METHYL-1H-IMIDAZOLE-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethyl 1-benzyl-4-methyl-1H-imidazole-2-carboxylate → ethyl 4-methyl-1H-imidazole-2-carboxylate (40253-44-9)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol; under 3040.2 Torr;

Reference yield: 90.0%

ethyl 1-benzyl-5-methyl-1H-imidazole-2-carboxylate → ethyl 4-methyl-1H-imidazole-2-carboxylate (40253-44-9)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol; under 3040.2 Torr;

DOI:10.1002/jhet.3321

Reference yield: 33.0%

glyoxylic acid ethyl ester (924-44-7) + 2-oxopropanal (78-98-8) → ethyl 4-methyl-1H-imidazole-2-carboxylate (40253-44-9)

Guidance literature:

With ammonia; In methanol; water; at 20 ℃;

upstream raw materials:

glyoxylic acid ethyl ester

2-oxopropanal

4-methyl-1H-imidazole

(2-trimethylethylsilylethoxy)methyl chloride

Downstream raw materials:

4-methyl-1H-imidazole-2-carboxylic acid

ethyl 5-methyl-1-phenyl-1H-imidazole-2-carboxylate

ethyl 4-bromo-5-methyl-1H-imidazole-2-carboxylate

Refernces

• 1、 -. "CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF". Paragraph 1411. . Retrieved 2018/04/17.
• 2、 -. "HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS AND COMBINATIONS THEREOF". Page/Page column 278. . Retrieved 2015/07/07.