Technology Process of 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-3,4'-dimethoxy-2'-(trifluoromethyl)biphenyl-4-carboxylic acid
There total 9 articles about 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-3,4'-dimethoxy-2'-(trifluoromethyl)biphenyl-4-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium hydroxide monohydrate; water;
In
1,4-dioxane;
at 45 ℃;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: N-iodo-succinimide; sulfuric acid
2.1: copper; tris-(dibenzylideneacetone)dipalladium(0) / dimethyl sulfoxide / 16 h / 80 °C
3.1: acetic acid / dichloromethane / 0.5 h / 20 °C
4.1: sodium cyanoborohydride / dichloromethane
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C
6.1: hydrogen / methanol / 20 °C
7.1: toluene-4-sulfonic acid; sodium nitrite / water; acetonitrile / 1 h / 20 °C
7.2: 20 °C
8.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Microwave irradiation
9.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 45 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium(0); N-iodo-succinimide; lithium hydroxide monohydrate; sulfuric acid; water; hydrogen; copper; sodium cyanoborohydride; sodium carbonate; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite;
In
1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; acetonitrile;
8.1: |Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: acetic acid / dichloromethane / 0.5 h / 20 °C
2.1: sodium cyanoborohydride / dichloromethane
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C
4.1: hydrogen / methanol / 20 °C
5.1: toluene-4-sulfonic acid; sodium nitrite / water; acetonitrile / 1 h / 20 °C
5.2: 20 °C
6.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Microwave irradiation
7.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 45 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide monohydrate; water; hydrogen; sodium cyanoborohydride; sodium carbonate; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; sodium nitrite;
In
1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile;
6.1: |Suzuki Coupling;