4-Amino-4'-chlorobenzophenone

Base Information

• Chemical Name: 4-Amino-4'-chlorobenzophenone
• CAS No.: 4913-77-3
• Molecular Formula: C13H10 Cl N O
• Molecular Weight: 231.681
• DSSTox Substance ID: DTXSID70393355
• Nikkaji Number: J80.921G
• Wikidata: Q82192108
• Mol file: 4913-77-3.mol

Synonyms:4-amino-4'-chlorobenzophenone

Chemical Property of 4-Amino-4'-chlorobenzophenone

Chemical Property:

• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 231.0450916
• Heavy Atom Count: 16
• Complexity: 240

Purity/Quality:

99%min ^*data from raw suppliers

4-Amino-4''-chlorobenzophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(=O)C2=CC=C(C=C2)Cl)N

Technology Process of 4-Amino-4'-chlorobenzophenone

There total 19 articles about 4-Amino-4'-chlorobenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(4-Chlorophenyl)(4-nitrophenyl)methanone (7497-60-1) → 4-amino-4'-chlorobenzophenone (4913-77-3)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 60 ℃; for 3h;

Reference yield: 93.0%

→ (4-Chlorophenyl)(4-nitrophenyl)methanone (7497-60-1) + 4-amino-4'-chlorobenzophenone (4913-77-3)

Guidance literature:

Reference yield: 87.0%

carbon monoxide (201230-82-2) + tributyl(4-chlorophenyl)stannane (17151-48-3) + p-aminoiodobenzene (540-37-4) → 4-amino-4'-chlorobenzophenone (4913-77-3)

Guidance literature:

With MCM-41-supported bidentate phosphine palladium⁽⁰⁾ complex; In N,N-dimethyl-formamide; at 80 ℃; for 6h; under 760.051 Torr;

DOI:10.1039/b914844m

upstream raw materials:

(4-Chlorophenyl)(4-nitrophenyl)methanone

4,4'-Dichlorobenzophenone

4-nitro-benzoyl chloride

chlorobenzene

Downstream raw materials:

4-chloro-4'-(1H-pyrrol-1-yl)benzophenone

(4-chlorophenyl)(4-methyl-6-quinolinyl)-methanone

(4-chloro-phenyl)-(1,2,3,4-tetrahydro-[6]quinolyl)-ketone

[6]quinolyl-(4-chloro-phenyl)-methanol

Refernces

• 1、 Xu, Qian,Yu, Gang,Liu, Min,Peng, Chang,Banks, M. Katherine,Xu, Weijian,Wu, Ruoxi,Lu, Yanbing. "Coumarin-surfactant modified polyoxometalate catalyzed cross dehydrogenative coupling of benzyl alcohol with the: Para -C-H of unprotected aniline". . p. 5133 - 5136. Retrieved 2018/10/24.
• 2、 -. "QUINOLINE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS". Paragraph 0510. . Retrieved 2015/09/28.