2-Cyano-3-trifluoromethylpyridine

Base Information

• Chemical Name: 2-Cyano-3-trifluoromethylpyridine
• CAS No.: 406933-21-9
• Molecular Formula: C7H3F3N2
• Molecular Weight: 172.109
• Hs Code.: 2933399090
• Mol file: 406933-21-9.mol

Synonyms:2-Cyano-3-trifluoromethylpyridine;3-Trifluoromethyl-2-pyridinecarbonitrile;3-(trifluoromethyl)pyridine-2-carbonitrile;2-pyridinecarbonitrile, 3-(trifluoromethyl)-;

Chemical Property of 2-Cyano-3-trifluoromethylpyridine

Chemical Property:

• Vapor Pressure: 0.038mmHg at 25°C
• Refractive Index: 1.457
• Boiling Point: 240.468 °C at 760 mmHg
• PKA: -2.75±0.10(Predicted)
• Flash Point: 99.232 °C
• PSA: 36.68000
• Density: 1.373 g/cm³
• LogP: 1.97208
• Storage Temp.: Room temperature.

Purity/Quality:

98%, ^*data from raw suppliers

2-Cyano-3-Trifluoromethylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Cyano-3-trifluoromethylpyridine

There total 6 articles about 2-Cyano-3-trifluoromethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

zinc(II) cyanide (557-21-1) + 2-chloro-3-trifluoromethyl-pyridine (65753-47-1) → 2-cyano-3-(trifluoromethyl)pyridine (406933-21-9)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 120 ℃; for 1h; Inert atmosphere;

Reference yield: 98.0%

2-chloro-3-trifluoromethyl-pyridine (65753-47-1) → 2-cyano-3-(trifluoromethyl)pyridine (406933-21-9)

Guidance literature:

With dicyanozinc; zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In DMF (N,N-dimethyl-formamide); dichloromethane; for 4h; Heating / reflux;

Reference yield: 52.0%

trimethylsilyl cyanide (7677-24-9) + 3-(trifluoromethyl)pyridine-N-oxide (22253-72-1) → 2-cyano-3-(trifluoromethyl)pyridine (406933-21-9)

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃; for 24h;

upstream raw materials:

2-chloro-3-trifluoromethyl-pyridine

dicyanozinc

trimethylsilyl cyanide

3-(trifluoromethyl)pyridine-N-oxide

Downstream raw materials:

2-cyano-3-(trifluoromethyl)-5-nitropyridine

5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile

5-isothiocyanato-3-(trifluoromethyl)pyridine-2-carbonitrile

7-[3-(trifluoromethyl)pyridin-2-yl]-N-[5-(trifluoromethyl)-pyridin-2-yl]-1,8-naphthyridin-4-amine

Refernces

• 1、 -. "Prostatic cancer treatment medicine". Paragraph 0019-0020; 0023-0024. . Retrieved 2019/03/26.
• 2、 -. "ANDROGEN RECEPTOR MODULATOR FOR TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES". Paragraph 0044; 0045. . Retrieved 2016/11/14.