Technology Process of (1R)-1-{[4-({2-[(3-fluorophenyl)amino]ethyl}amino)-1-piperidinyl]methyl}-1,2-dihydro-4H,9H-imidazo[1,2,3-ij]-1,8-naphthyridine-4,9-dione
There total 4 articles about (1R)-1-{[4-({2-[(3-fluorophenyl)amino]ethyl}amino)-1-piperidinyl]methyl}-1,2-dihydro-4H,9H-imidazo[1,2,3-ij]-1,8-naphthyridine-4,9-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(1R)-1-[(4-amino-1-piperidinyl)methyl]-1,2-dihydro-4H,9H-imidazo[1,2,3-ij]-1,8-naphthyridine-4,9-dione;
With
potassium carbonate;
In
methanol; acetonitrile;
at 20 ℃;
for 0.166667h;
2-[(3-fluorophenyl)amino]ethyl methanesulfonate;
In
methanol; acetonitrile;
at 20 - 80 ℃;
for 47h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium hydroxide / ethanol / 2 h / 90 °C / Inert atmosphere
2.1: triethylamine / dichloromethane / 0.33 h / 20 °C / Inert atmosphere
2.2: 20 h / 0 - 20 °C
3.1: potassium carbonate / methanol; acetonitrile / 0.17 h / 20 °C
3.2: 47 h / 20 - 80 °C / Inert atmosphere
With
potassium carbonate; triethylamine; potassium hydroxide;
In
methanol; ethanol; dichloromethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: pyridine / dichloromethane / 20 h / 0 - 20 °C / Inert atmosphere
2.1: potassium hydroxide / ethanol / 2 h / 90 °C / Inert atmosphere
3.1: triethylamine / dichloromethane / 0.33 h / 20 °C / Inert atmosphere
3.2: 20 h / 0 - 20 °C
4.1: potassium carbonate / methanol; acetonitrile / 0.17 h / 20 °C
4.2: 47 h / 20 - 80 °C / Inert atmosphere
With
pyridine; potassium carbonate; triethylamine; potassium hydroxide;
In
methanol; ethanol; dichloromethane; acetonitrile;