2-(2,4-dimethoxybenzene)-2-oxoacetic acid

Base Information

• Chemical Name: 2-(2,4-dimethoxybenzene)-2-oxoacetic acid
• CAS No.: 26767-17-9
• Molecular Formula: C₁₀H₁₀O₅
• Molecular Weight: 210.186
• Mol file: 26767-17-9.mol

Synonyms:2-(2,4-dimethoxybenzene)-2-oxoacetic acid

Chemical Property of 2-(2,4-dimethoxybenzene)-2-oxoacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(2,4-dimethoxybenzene)-2-oxoacetic acid

There total 7 articles about 2-(2,4-dimethoxybenzene)-2-oxoacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2',4'-dimethoxyacetophenone (829-20-9) → 2-(2,4-dimethoxybenzene)-2-oxoacetic acid (26767-17-9)

Guidance literature:

With selenium(IV) oxide; In pyridine; 1.) 110-90 deg C, 1 h, 2.) 90 deg C, 4 h;

DOI:10.1021/jo00113a029

Reference yield: 79.0%

(2,4-dimethoxyphenyl)-glyoxalic acid ethyl ester (6592-19-4) → 2-(2,4-dimethoxybenzene)-2-oxoacetic acid (26767-17-9)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 20 ℃; for 0.25h;

DOI:10.1055/s-0033-1340565

Reference yield: 73.0%

2,4-dimethoxystyrene (40243-84-3) → 2-(2,4-dimethoxybenzene)-2-oxoacetic acid (26767-17-9)

Guidance literature:

With tert.-butylhydroperoxide; water; tetra-(n-butyl)ammonium iodide; In acetonitrile; at 90 ℃; for 12h; Inert atmosphere; Glovebox; Schlenk technique; Green chemistry;

DOI:10.1021/acs.orglett.1c02021

upstream raw materials:

ethyl cyanoformate

1,3-Dimethoxybenzene

2',4'-dimethoxyacetophenone

(2,4-dimethoxyphenyl)-glyoxalic acid ethyl ester

Downstream raw materials:

Cyclododecyl (2,4-dimethoxybenzoyl)formate

[(NH3)3Co(μ-OH)2(μ-(2,4-dimethoxyphenyl)glyoxylato)Co(NH3)3](ClO4)3

ethyl (E)-3-[(2S,3R,4R)-4-(2,4-dimethoxyphenyl)-4-hydroxy-5-oxo-1,2-diphenylpyrrolidin-3-yl]acrylate

2-(2,4-dimethoxyphenyl)-2-oxo-N-phenylacetamide

Refernces

• 1、 Song, Tao,Ma, Zhiming,Wang, Xiaoxue,Yang, Yong. "Synthesis of α-Keto Acids via Oxidation of Alkenes Catalyzed by a Bifunctional Iron Nanocomposite". supporting information. p. 5917 - 5921. Retrieved 2021/07/31.
• 2、 Li, Ping-Gui,Zhu, Hao,Fan, Min,Yan, Cheng,Shi, Kai,Chi, Xi-Wen,Zou, Liang-Hua. "Copper-catalyzed coupling of anthranils and α-keto acids: Direct synthesis of α-ketoamides". supporting information. p. 5902 - 5907. Retrieved 2019/06/24.