Technology Process of 4-[3-(3-aminobenzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl]butyric acid
There total 5 articles about 4-[3-(3-aminobenzoyl)-1H-pyrrolo[2,3-b]pyridin-1-yl]butyric acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
1,4-dioxane; ethanol;
for 4h;
under 3040 Torr;
DOI:10.1248/cpb.49.799
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: AlCl3 / CH2Cl2 / 0.17 h / 20 °C
1.2: 19 percent / CH2Cl2 / 1 h
2.1: 83.9 percent / K2CO3 / dimethylformamide / 4 h / 50 °C
3.1: 98.9 percent / 4N aq. NaOH / ethanol / 0.67 h / Heating
4.1: 100 percent / H2 / 10 percent Pd/C / dioxane; ethanol / 4 h / 3040 Torr
With
sodium hydroxide; aluminium trichloride; hydrogen; potassium carbonate;
palladium on activated charcoal;
In
1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
1.2: Friedel-Crafts acylation;
DOI:10.1248/cpb.49.799
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: AlCl3 / CH2Cl2 / 0.17 h / 20 °C
1.2: 19 percent / CH2Cl2 / 1 h
2.1: 83.9 percent / K2CO3 / dimethylformamide / 4 h / 50 °C
3.1: 98.9 percent / 4N aq. NaOH / ethanol / 0.67 h / Heating
4.1: 100 percent / H2 / 10 percent Pd/C / dioxane; ethanol / 4 h / 3040 Torr
With
sodium hydroxide; aluminium trichloride; hydrogen; potassium carbonate;
palladium on activated charcoal;
In
1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
1.2: Friedel-Crafts acylation;
DOI:10.1248/cpb.49.799