(-)-Metoprolol hydrochloride

Base Information

• Chemical Name: (-)-Metoprolol hydrochloride
• CAS No.: 114218-35-8
• Molecular Formula: C₁₅H₂₅NO₃*ClH
• Molecular Weight: 303.829
• Mol file: 114218-35-8.mol

Synonyms:(-)-Metoprolol hydrochloride

Chemical Property of (-)-Metoprolol hydrochloride

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-Metoprolol hydrochloride

There total 4 articles about (-)-Metoprolol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

S-(-)-metoprolol (81024-42-2,37350-58-6) → (-)-Metoprolol hydrochloride (114218-35-8,56392-18-8)

Guidance literature:

With hydrogenchloride; In methanol; for 1h; Heating;

DOI:10.3987/com-98-8169

Reference yield:

N-isopropyl-3-<<4'-(2''-methoxyethyl)phenyl>oxy>-2-oxo-1-propylamine hydrochloride (128084-02-6) → (+)-Metoprolol hydrochloride (68985-04-6,56392-18-8) + (-)-Metoprolol hydrochloride (114218-35-8,56392-18-8)

Guidance literature:

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; hydrogen; triethylamine; (2S,4S)-N-(methylcarbamoyl)-4-(dicyclohexylphosphino)-2-<(diphenylphosphino)methyl>pyrrolidine; In methanol; at 50 ℃; for 20h; under 14710.2 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

Reference yield:

2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane (56718-70-8) → (-)-Metoprolol hydrochloride (114218-35-8,56392-18-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 45 percent / Salen-Co(III)OAc / H₂O / Ambient temperature

2: 90 percent / H₂O / 6 h / Heating

3: 90 percent / 11N HCl / methanol / 1 h / Heating

With hydrogenchloride; Salen-Co(III)OAc; In methanol; water;

DOI:10.3987/com-98-8169

upstream raw materials:

N-isopropyl-3-<<4'-(2''-methoxyethyl)phenyl>oxy>-2-oxo-1-propylamine hydrochloride

S-(-)-metoprolol

2-[4-(2'-methoxyethyl)phenoxymethyl]oxirane

(2S)-2-{[4-(2-Methoxyethyl)phenoxy]methyl}oxirane

Refernces

• 1、 Sukuraba,Takahashi,Takeda,Achiwa. "Efficient asymmetric hydrogenation of α-amino ketone derivatives. A highly enantioselective synthesis of phenylephrine, levamisole, carnitine and propranolol". . p. 738 - 747. Retrieved 2007/10/02.