1H-Benzoimidazole-2-carboxylic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide

Base Information

• Chemical Name: 1H-Benzoimidazole-2-carboxylic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide
• CAS No.: 795296-63-8
• Molecular Formula: C₁₈H₁₆N₄O₃
• Molecular Weight: 336.35
• Mol file: 795296-63-8.mol

Synonyms:1H-Benzoimidazole-2-carboxylic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide

Chemical Property of 1H-Benzoimidazole-2-carboxylic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1H-Benzoimidazole-2-carboxylic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide

There total 1 articles about 1H-Benzoimidazole-2-carboxylic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-benzimidazolecarboxylic acid (2849-93-6) + 4-(4-aminophenyl)morpholin-3-one (438056-69-0) → 1H-Benzoimidazole-2-carboxylic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide (795296-63-8)

Guidance literature:

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

1H-Benzoimidazole-2-carboxylic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide (795296-63-8) + 2-bromo-N-(5-chloropyridin-2-yl)acetamide (90931-34-3) → 1-[(5-chloro-pyridin-2-ylcarbamoyl)-methyl]-1H-benzoimidazole-2-carboxylic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide hydrochloride

Guidance literature:

1H-Benzoimidazole-2-carboxylic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide; 2-bromo-N-(5-chloropyridin-2-yl)acetamide; With caesium carbonate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 4h;

With hydrogenchloride; In water;

upstream raw materials:

2-benzimidazolecarboxylic acid

4-(4-aminophenyl)morpholin-3-one

Refernces