Technology Process of 4-(4-pyridinyl)-N-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine
There total 3 articles about 4-(4-pyridinyl)-N-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(4-(trifluoromethyl)phenyl)thiourea; 4-bromoacetylpyridine hydrobromide;
In
ethanol;
for 3h;
Heating;
Reflux;
With
ammonia;
In
ethanol; water;
at 20 ℃;
for 2h;
pH=~ 8;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogen bromide; bromine; acetic acid / 0 - 75 °C
2.1: ethanol / 3 h / Heating; Reflux
2.2: 2 h / 20 °C / pH ~ 8
With
hydrogen bromide; bromine; acetic acid;
In
ethanol;
2.1: Hantzsch thiazole synthesis;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogenchloride / water / 16 h / 100 °C
2.1: ethanol / 3 h / Heating; Reflux
2.2: 2 h / 20 °C / pH ~ 8
With
hydrogenchloride;
In
ethanol; water;
2.1: Hantzsch thiazole synthesis;