4-amino-5-chloro-N-hydroxy-2-methoxybenzamidine

Base Information

• Chemical Name: 4-amino-5-chloro-N-hydroxy-2-methoxybenzamidine
• CAS No.: 147805-12-7
• Molecular Formula: C₈H₁₀ClN₃O₂
• Molecular Weight: 215.639
• Mol file: 147805-12-7.mol

Synonyms:4-amino-5-chloro-N-hydroxy-2-methoxybenzamidine

Chemical Property of 4-amino-5-chloro-N-hydroxy-2-methoxybenzamidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 4-amino-5-chloro-N-hydroxy-2-methoxybenzamidine

There total 4 articles about 4-amino-5-chloro-N-hydroxy-2-methoxybenzamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-amino-5-chloro-2-methoxybenzonitrile (31380-91-3) → 4-amino-5-chloro-N-hydroxy-2-methoxybenzamidine (147805-12-7)

Guidance literature:

With hydroxylamine hydrochloride; potassium carbonate; In ethanol; for 20h; Heating;

DOI:10.1248/cpb.47.120

Reference yield: 40.0%

4-amino-5-chloro-2-methoxybenzonitrile (31380-91-3) → 2-Methoxy-4-amino-5-chlorobenzamide-oxime (147805-12-7)

Guidance literature:

With hydroxylamine hydrochloride; sodium; In methanol;

Reference yield:

4-amino-5-chloro-2-methoxybenzamide (24190-74-7) → 4-amino-5-chloro-N-hydroxy-2-methoxybenzamidine (147805-12-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / POCl₃ / 0.5 h / 50 °C

2: 75 percent / hydroxylamine hydrochloride, K₂CO₃ / ethanol / 20 h / Heating

With hydroxylamine hydrochloride; potassium carbonate; trichlorophosphate; In ethanol;

DOI:10.1248/cpb.47.120

upstream raw materials:

4-amino-5-chloro-2-methoxybenzonitrile

4-amino-5-chloro-2-methoxybenzamide

1H-1,2,3-benzotriazol-1-yl 4-amino-5-chloro-2-methoxybenzoate

Downstream raw materials:

2-chloro-5-methoxy-4-<5-(2-piperidylmethyl)-1,2,4-oxadiazol-3-yl>aniline

Refernces

• 1、 -. "5-HT4 receptor antagonists". . . Retrieved 2008/06/13.