2-CHLOROBENZOIC ANHYDRIDE

Base Information

• Chemical Name: 2-CHLOROBENZOIC ANHYDRIDE
• CAS No.: 49619-43-4
• Molecular Formula: C14H8 Cl2 O3
• Molecular Weight: 295.122
• Mol file: 49619-43-4.mol

Synonyms:Benzoicacid, 2-chloro-, anhydride (9CI); Benzoic acid, o-chloro-, anhydride (6CI,7CI);2-Chlorobenzoic acid anhydride; 2-Chlorobenzoic anhydride; o-Chlorobenzoic acidanhydride; o-Chlorobenzoic anhydride

Chemical Property of 2-CHLOROBENZOIC ANHYDRIDE

Chemical Property:

• Vapor Pressure: 6.84E-08mmHg at 25°C
• Refractive Index: 1.607
• Boiling Point: 438.6°C at 760 mmHg
• Flash Point: 182.2°C
• PSA: 43.37000
• Density: 1.401g/cm³
• LogP: 3.99060

Purity/Quality:

97% ^*data from raw suppliers

2-CHLOROBENZOIC ANHYDRIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLOROBENZOIC ANHYDRIDE

There total 9 articles about 2-CHLOROBENZOIC ANHYDRIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ortho-chlorobenzoic acid (118-91-2) → 2-chlorobenzoic anhydride (49619-43-4)

Guidance literature:

With 1-ethyl-piperidine; Phenyl N-phenylphosphoramidochloridate; In dichloromethane; for 0.5h; Ambient temperature;

DOI:10.1055/s-1981-29391

Reference yield: 96.0%

o-chlorobenzoyl chloride (609-65-4) → 2-chlorobenzoic anhydride (49619-43-4)

Guidance literature:

With sodium hydrogencarbonate; In acetonitrile; at 45 ℃; for 5h; ultrasound;

DOI:10.1080/00397919708005024

Reference yield: 80.0%

2-chloro-benzaldehyde (89-98-5) → 2-chlorobenzoic anhydride (49619-43-4)

Guidance literature:

With tert.-butylhydroperoxide; In acetonitrile; at 80 ℃; for 2h;

DOI:10.1039/c8ra03870h

upstream raw materials:

pyridine

o-chlorobenzoyl chloride

ortho-chlorobenzoic acid

carbon monoxide

Downstream raw materials:

2-chlorothiobenzoic acid S-benzyl ester

C₁₄H₁₈O₂

2-chloro-N-(2-(3,4-dimethoxyphenyl)-benzoxazol-5-yl)-benzamide

o-chlorobenzoyl azide

Refernces

• 1、 Spránitz, Péter,Soregi, Petra,Botlik, Bence Béla,Berta, Máté,Soós, Tibor. "Organocatalytic Desymmetrisation of Fittig's Lactones: Deuterium as a Reporter Tag for Hidden Racemisation". . p. 1263 - 1272. Retrieved 2019/02/26.
• 2、 Kaur, Avneet,Pathak, Dharam P.,Sharma, Vidushi,Wakode, Sharad. "Synthesis, molecular docking, and pharmacological evaluation of N-(2-(3,5-dimethoxyphenyl)benzoxazole-5-yl)benzamide derivatives as selective COX-2 inhibitors and anti-inflammatory agents". . . Retrieved 2018/05/15.