C₃₃H₃₃NO₆

Base Information

• Chemical Name: C₃₃H₃₃NO₆
• CAS No.: 1489240-28-9
• Molecular Formula: C₃₃H₃₃NO₆
• Molecular Weight: 539.628
• Mol file: 1489240-28-9.mol

Synonyms:C₃₃H₃₃NO₆

Chemical Property of C₃₃H₃₃NO₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₃H₃₃NO₆

There total 3 articles about C₃₃H₃₃NO₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

tert-butyl (naphthalen-2-yl(phenylsulfonyl)methyl)carbamate (479423-32-0) + malonic acid dibenzyl ester (15014-25-2) + 1-(phenylethynyl)naphthalen-2-ol (1396512-33-6) → C33H33NO6 (1489240-28-9) + C24H18O3S

Guidance literature:

tert-butyl (naphthalen-2-yl(phenylsulfonyl)methyl)carbamate; malonic acid dibenzyl ester; With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea; sodium carbonate; In dichloromethane; water; at 0 ℃; for 24h;

1-(phenylethynyl)naphthalen-2-ol; With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea; boric acid; L-proline; In chloroform; at 25 ℃; for 48h; enantioselective reaction;

DOI:10.1021/acs.orglett.8b02087

Reference yield: 88.0%

tert-butyl naphthalen-2-ylmethylenecarbamate (479423-45-5) + malonic acid dibenzyl ester (15014-25-2) → C33H33NO6 (1489240-28-9)

Guidance literature:

malonic acid dibenzyl ester; With triethylamine; 2,6-bis<(S)-4'-benzyloxazolin-2'-yl>pyridine; calcium iodide; In toluene; at 80 ℃; for 0.5h; Inert atmosphere;

tert-butyl naphthalen-2-ylmethylenecarbamate; In toluene; at -78 ℃; for 16h; enantioselective reaction; Inert atmosphere;

DOI:10.1002/asia.201300102

Reference yield: 80.0%

tert-butyl (naphthalen-2-yl(phenylsulfonyl)methyl)carbamate (479423-32-0) + malonic acid dibenzyl ester (15014-25-2) → C33H33NO6 (1489240-28-9)

Guidance literature:

With potassium carbonate; In water; toluene; at -15 ℃; for 48h; enantioselective reaction;

DOI:10.1002/cctc.201300089

upstream raw materials:

tert-butyl (naphthalen-2-yl(phenylsulfonyl)methyl)carbamate

malonic acid dibenzyl ester

tert-butyl naphthalen-2-ylmethylenecarbamate

1-(phenylethynyl)naphthalen-2-ol

Refernces

• 1、 Zhu, Hao,Jiang, Xianxing,Li, Xinghua,Hou, Chen,Jiang, Yu,Hou, Ke,Wang, Rui,Li, Yanfeng. "Highly enantioselective synthesis of N-Protected β-Amino malonates catalyzed by magnetically separable heterogeneous rosin-derived amino thiourea catalysts: A Stereocontrolled Approach to β-Amino Acids". . p. 2187 - 2190. Retrieved 2013/08/23.