2-BENZYL-OCTAHYDRO-PYRROLO[3,4-C]PYRIDINE

Base Information

• Chemical Name: 2-BENZYL-OCTAHYDRO-PYRROLO[3,4-C]PYRIDINE
• CAS No.: 351370-98-4
• Molecular Formula: C14H20N2
• Molecular Weight: 216.326
• Hs Code.: 2933990090
• Mol file: 351370-98-4.mol

Synonyms:2-benzyloctahydro-1H-pyrrolo[3.4-c]pyridine;2-Benzyl-octahydro-pyrrol-3,4-cpyridine;2-Benzyloctahydropyrrolo[3,4-c]pyridine;

Chemical Property of 2-BENZYL-OCTAHYDRO-PYRROLO[3,4-C]PYRIDINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.558
• Boiling Point: 317.725 °C at 760 mmHg
• Flash Point: 127.296 °C
• PSA: 15.27000
• Density: 1.05 g/cm³
• LogP: 1.99460
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Benzyl-octahydro-1H-pyrrolo[3,4-c]pyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BENZYL-OCTAHYDRO-PYRROLO[3,4-C]PYRIDINE

There total 7 articles about 2-BENZYL-OCTAHYDRO-PYRROLO[3,4-C]PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-benzylhexahydro-1H-pyrrolo[3,4-c]pyridine-4(2H)-one (851526-87-9) → 2-benzyloctahydro-1H-pyrrolo[3.4-c]pyridine (351370-98-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 50 ℃; for 2h;

Reference yield:

cinchomeronic anhydride (4664-08-8) → 2-benzyloctahydro-1H-pyrrolo[3.4-c]pyridine (351370-98-4)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic anhydride / 1 h / 0 - 20 °C / Reflux

2: acetic anhydride / 4 h / 110 °C

3: palladium on carbon; hydrogen / methanol / 60 °C / 22502.3 Torr

4: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; palladium on carbon; hydrogen; acetic anhydride; In tetrahydrofuran; methanol;

Reference yield:

2-benzylhexahydro-1H-pyrrolo[3.4-c]pyridine-1,3(2H)-dione (939793-58-5) → 2-benzyloctahydro-1H-pyrrolo[3.4-c]pyridine (351370-98-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 6h; Reflux; Inert atmosphere;

upstream raw materials:

2-benzylhexahydro-1H-pyrrolo[3,4-c]pyridine-4(2H)-one

3,4-pyridinedicarboximide

benzyl bromide

2-benzylhexahydro-1H-pyrrolo[3.4-c]pyridine-1,3(2H)-dione

Downstream raw materials:

tert-butyl hexahydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxylate

tert-butyl 2-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)hexahydro-1H-pyrrolo[3,4-c] pyridine-5(6H)-carboxylate

N-(3-chloro-4-fluorophenyl)-6-(3-(hexahydro-1H-pyrrolo[3.4-c]pyridin-2(3H)-yl)propoxy)-7-methoxyquinazolin-4-amine

Refernces

• 1、 -. "AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE". . . Retrieved 2014/08/19.
• 2、 -. "Substituted diazabicycloalkane derivatives". Page/Page column 35. . Retrieved 2010/02/11.