17-Hydroxy-21-iodoprogesterone

Base Information

• Chemical Name: 17-Hydroxy-21-iodoprogesterone
• CAS No.: 4470-79-5
• Molecular Formula: C21H29 I O3
• Molecular Weight: 456.364
• Mol file: 4470-79-5.mol

Synonyms:Progesterone,17-hydroxy-21-iodo- (6CI); 17-Hydroxy-21-iodoprogesterone; 17a-Hydroxy-21-iodopregn-4-ene-3,20-dione;17a-Hydroxy-21-iodoprogesterone

Chemical Property of 17-Hydroxy-21-iodoprogesterone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 17-Hydroxy-21-iodoprogesterone

There total 7 articles about 17-Hydroxy-21-iodoprogesterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.3%

17-hydroxyprogesterone (68-96-2) → 21-Iodo-17α-hydroxypregn-4-en-3,20-dione (4470-79-5)

Guidance literature:

With iodine; calcium chloride; calcium oxide; In methanol; dichloromethane; water; 1.) 10-12 deg C above room temp., 15 min., 2.) room temp., 30 min.;

DOI:10.1007/BF00764888

Reference yield:

Sulfuric acid 2-((8R,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl ester p-tolyl ester → 21-Iodo-17α-hydroxypregn-4-en-3,20-dione (4470-79-5)

Guidance literature:

With sodium iodide; In acetone;

DOI:10.1021/jm00380a004

Reference yield:

Cortexolone (152-58-9) → 21-Iodo-17α-hydroxypregn-4-en-3,20-dione (4470-79-5)

Guidance literature:

Multi-step reaction with 2 steps

2: NaI

With sodium iodide;

upstream raw materials:

17-hydroxyprogesterone

21-p-toluenesulfonate of 17α,21-dihydroxy-4-pregnene-3,20-dione

Cortexolone

Downstream raw materials:

17α-hydroxy-17β-(2-isopropylamino-thiazol-4-yl)-androst-4-en-3-one

17β-[2-(2,3-dichloro-anilino)-thiazol-4-yl]-17α-hydroxy-androst-4-en-3-one

17β-[2-(2,5-dichloro-anilino)-thiazol-4-yl]-17α-hydroxy-androst-4-en-3-one

17β-[2-(2-chloro-anilino)-thiazol-4-yl]-17α-hydroxy-androst-4-en-3-one

Refernces

• 1、 Ryakhovskaya, M. I.,Popova, E. V.,Grinenko, G. S.. "SYNTHESIS OF CORTEXOLONE PHOSPHATE". . p. 57 - 59. Retrieved 2007/10/02.