methyl 2-fluoro-4-formyl-5-methyl benzoate

Base Information

• Chemical Name: methyl 2-fluoro-4-formyl-5-methyl benzoate
• CAS No.: 1621165-17-0
• Molecular Formula: C₁₀H₉FO₃
• Molecular Weight: 196.178
• Mol file: 1621165-17-0.mol

Synonyms:methyl 2-fluoro-4-formyl-5-methyl benzoate

Chemical Property of methyl 2-fluoro-4-formyl-5-methyl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl 2-fluoro-4-formyl-5-methyl benzoate

There total 5 articles about methyl 2-fluoro-4-formyl-5-methyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methyl 2-fluoro-5-methyl-4-vinylbenzoate → methyl 2-fluoro-4-formyl-5-methyl benzoate (1621165-17-0)

Guidance literature:

methyl 2-fluoro-5-methyl-4-vinylbenzoate; With osmium(VIII) oxide; In tetrahydrofuran; water; tert-butyl alcohol; at 25 ℃; for 0.5h;

With sodium periodate; In tetrahydrofuran; water; tert-butyl alcohol; at 25 ℃; for 16h;

Reference yield: 41.0%

4-dibromo-5-fluoro-2-methylbenzaldehyde (861928-26-9) + methanol (67-56-1) + carbon monoxide (201230-82-2) → methyl 2-fluoro-4-formyl-5-methyl benzoate (1621165-17-0)

Guidance literature:

4-dibromo-5-fluoro-2-methylbenzaldehyde; methanol; carbon monoxide; With triethylamine; In N,N-dimethyl-formamide; for 0.166667h;

With bis-triphenylphosphine-palladium(II) chloride; at 70 ℃; for 18h;

Reference yield:

1-bromo-2-fluoro-4-iodo-5-methylbenzene (861928-20-3) → methyl 2-fluoro-4-formyl-5-methyl benzoate (1621165-17-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide / diethyl ether / 2.5 h / -100 - 20 °C

2.1: triethylamine / N,N-dimethyl-formamide / 0.17 h

2.2: 18 h / 70 °C

With triethylamine; N,N-dimethyl-formamide; In diethyl ether; N,N-dimethyl-formamide;

upstream raw materials:

1-bromo-2-fluoro-4-iodo-5-methylbenzene

4-dibromo-5-fluoro-2-methylbenzaldehyde

methanol

carbon monoxide

Downstream raw materials:

2-fluoro-4-formyl-N,5-dimethylbenzamide

Refernces

• 1、 -. "IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF". . . Retrieved 2014/08/19.