1,4-BIS[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE DIHYDROCHLORIDE

Base Information

• Chemical Name: 1,4-BIS[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE DIHYDROCHLORIDE
• CAS No.: 346451-15-8
• Molecular Formula: C₃₀H₂₈Cl₂N₂
• Molecular Weight: 487.472
• Mol file: 346451-15-8.mol

Synonyms:1,4-BIS[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE DIHYDROCHLORIDE

Chemical Property of 1,4-BIS[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE DIHYDROCHLORIDE

Chemical Property:

• Boiling Point: 270-275 °C(Press: 1 Torr)
• PKA: 5.85±0.10(Predicted)
• PSA: 6.48000
• Density: 1.228±0.06 g/cm3(Predicted)
• LogP: 8.96980
• Storage Temp.: Hygroscopic, Refrigerator, Under inert atmosphere
• Solubility.: Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly, Heated), Methanol (Sli

Purity/Quality:

98%Min ^*data from raw suppliers

1,4-Bis((4-chlorophenyl)(phenyl)methyl)piperazinedihydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,4-Bis[(4-chlorophenyl)phenylmethyl]piperazine is an impurity of Buclizine (B689450), an antiemetic agent.

Technology Process of 1,4-BIS[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE DIHYDROCHLORIDE

There total 3 articles about 1,4-BIS[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE DIHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperazine (110-85-0) + 1-chloro-4-(chloro(phenyl)methyl)benzene (134-83-8,60035-71-4) → N-(4-chlorobenzhydryl)piperazine (303-26-4) + 1,4-bis-(4-chloro-benzhydryl)-piperazine (346451-15-8)

Guidance literature:

With potassium carbonate; In acetonitrile; at 85 ℃; Sealed tube;

DOI:10.1002/jlcr.3298

Reference yield:

aq. Na2CO3 + 1-chloro-4-(chloro(phenyl)methyl)benzene (134-83-8,60035-71-4) + N-(4-chlorobenzhydryl)piperazine (303-26-4) → 1,4-bis-(4-chloro-benzhydryl)-piperazine (346451-15-8)

Guidance literature:

With triethylamine; In dichloromethane;

Reference yield:

piperazine (110-85-0) + 1-chloro-4-(chloro(phenyl)methyl)benzene (134-83-8,60035-71-4) → 1,4-bis-(4-chloro-benzhydryl)-piperazine (346451-15-8)

Guidance literature:

With triethylamine; at 170 ℃;

upstream raw materials:

piperazine

1-chloro-4-(chloro(phenyl)methyl)benzene

N-(4-chlorobenzhydryl)piperazine

Refernces

• 1、 -. "H1—histamine receptor antagonists". . . Retrieved 2008/06/13.