dibenzyl (1,1-dioxido-4-oxo-3-phenyl-4H-thiochromen-2-yl)methyl phosphate

Base Information

• Chemical Name: dibenzyl (1,1-dioxido-4-oxo-3-phenyl-4H-thiochromen-2-yl)methyl phosphate
• CAS No.: 1369964-82-8
• Molecular Formula: C₃₀H₂₅O₇PS
• Molecular Weight: 560.564
• Mol file: 1369964-82-8.mol

Synonyms:dibenzyl (1,1-dioxido-4-oxo-3-phenyl-4H-thiochromen-2-yl)methyl phosphate

Chemical Property of dibenzyl (1,1-dioxido-4-oxo-3-phenyl-4H-thiochromen-2-yl)methyl phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dibenzyl (1,1-dioxido-4-oxo-3-phenyl-4H-thiochromen-2-yl)methyl phosphate

There total 8 articles about dibenzyl (1,1-dioxido-4-oxo-3-phenyl-4H-thiochromen-2-yl)methyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

phosphoric acid dibenzyl ester (1623-08-1) + 2-diazomethyl-3-phenyl-4H-sulfonylchromen (1369964-75-9) → dibenzyl (1,1-dioxido-4-oxo-3-phenyl-4H-thiochromen-2-yl)methyl phosphate (1369964-82-8)

Guidance literature:

With hydrogenchloride; In chloroform; water; at 60 ℃; for 4h; pH=4; Inert atmosphere;

DOI:10.1055/s-0031-1290326

Reference yield:

2-methyl-4H-thiochromen-4-one (771-40-4) → dibenzyl (1,1-dioxido-4-oxo-3-phenyl-4H-thiochromen-2-yl)methyl phosphate (1369964-82-8)

Guidance literature:

Multi-step reaction with 7 steps

1: ammonium cerium (IV) nitrate; iodine / acetonitrile / 60 °C / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / water; N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

3: selenium(IV) oxide / 1,2-dichloro-benzene / 150 °C / Inert atmosphere

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C / Inert atmosphere

5: ethanol / 24 h / 20 °C / Inert atmosphere

6: sodium hydroxide / dichloromethane; water / 20 °C / Inert atmosphere

7: hydrogenchloride / chloroform; water / 4 h / 60 °C / pH 4 / Inert atmosphere

With hydrogenchloride; selenium(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; ammonium cerium (IV) nitrate; iodine; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; 1,2-dichloro-benzene; acetonitrile; 2: Suzuki coupling / 6: Bamford-Stevens reaction;

DOI:10.1055/s-0031-1290326

Reference yield:

4-oxo-3-phenyl-4H-thiochromene-2-carbaldehyde (1345691-05-5) → dibenzyl (1,1-dioxido-4-oxo-3-phenyl-4H-thiochromen-2-yl)methyl phosphate (1369964-82-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: ethanol / 24 h / 20 °C / Inert atmosphere

3: sodium hydroxide / dichloromethane; water / 20 °C / Inert atmosphere

4: hydrogenchloride / chloroform; water / 4 h / 60 °C / pH 4 / Inert atmosphere

With hydrogenchloride; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In ethanol; dichloromethane; chloroform; water; 3: Bamford-Stevens reaction;

DOI:10.1055/s-0031-1290326

upstream raw materials:

2-methyl-4H-thiochromen-4-one

4-oxo-3-phenyl-4H-thiochromene-2-carbaldehyde

C₁₆H₁₀O₄S

C₂₃H₁₈N₂O₅S₂

Downstream raw materials:

phosphoric acid dibenzyl ester

Refernces