2,5-ANHYDRO-D-GLUCITOL-1,6-DIPHOSPHATE

Base Information

• Chemical Name: 2,5-ANHYDRO-D-GLUCITOL-1,6-DIPHOSPHATE
• CAS No.: 4429-47-4
• Molecular Formula: C₆H₁₄O₁₁P₂
• Molecular Weight: 324.118
• Mol file: 4429-47-4.mol

Synonyms:Glucitol,2,5-anhydro-, 1,6-diphosphate (7CI); Glucitol, 2,5-anhydro-, 1,6-diphosphate,D- (8CI); 2,5-Anhydro-D-glucitol 1,6-bisphosphate; 2,5-Anhydro-D-glucitol1,6-diphosphate; 2,5-Anhydroglucitol 1,6-bisphosphate

Chemical Property of 2,5-ANHYDRO-D-GLUCITOL-1,6-DIPHOSPHATE

Chemical Property:

• PSA: 202.83000
• LogP: -2.30580
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility.: Methanol (Slightly), Water (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

2,5-Anhydro-D-glucitol-1,6-diphosphate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An effective competitive inhibitor of phosphofructokinase (EC 2.7.1.11)

Technology Process of 2,5-ANHYDRO-D-GLUCITOL-1,6-DIPHOSPHATE

There total 5 articles about 2,5-ANHYDRO-D-GLUCITOL-1,6-DIPHOSPHATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C30H30O11P2 (300807-67-4) → D-Fructose-1,6-diphosphat (4429-47-4,671-08-9)

Guidance literature:

With hydrogen; platinum(IV) oxide; In methanol; for 18h;

DOI:10.1021/jo0003908

Reference yield:

1-deoxy-1-β-ethenyl-2,3,5-tri-O-benzyl-L-xylose (162239-10-3) → D-Fructose-1,6-diphosphat (4429-47-4,671-08-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 4-methylmorpholine N-oxide; OsO₄ / tetrahydrofuran; H₂O / 20 °C

1.2: 48 percent / NaIO₄ / methanol; tetrahydrofuran; H₂O / 2 h / 20 °C

2.1: 92 percent / NaBH₄ / ethanol / 2 h

3.1: 61 percent / H₂ / Pd/C / methanol / 18 h / 20 °C

4.1: 45 percent / DMAP; pyridine / 18 h / 0 - 20 °C

5.1: 100 percent / H₂ / PtO₂ / methanol / 18 h

With pyridine; dmap; sodium tetrahydroborate; osmium(VIII) oxide; hydrogen; 4-methylmorpholine N-oxide; platinum(IV) oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; water; 1.1: dihydroxylation / 1.2: Oxidation / 2.1: Reduction / 3.1: Hydrogenolysis / 4.1: Condensation / 5.1: Hydrogenolysis;

DOI:10.1021/jo0003908

Reference yield:

2,5-anhydro-D-glucitol (27826-73-9) → D-Fructose-1,6-diphosphat (4429-47-4,671-08-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / DMAP; pyridine / 18 h / 0 - 20 °C

2: 100 percent / H₂ / PtO₂ / methanol / 18 h

With pyridine; dmap; hydrogen; platinum(IV) oxide; In methanol; 1: Condensation / 2: Hydrogenolysis;

DOI:10.1021/jo0003908

upstream raw materials:

C₃₀H₃₀O₁₁P₂

1-deoxy-1-β-ethenyl-2,3,5-tri-O-benzyl-L-xylose

2,5-anhydro-D-glucitol

(2S,3S,4R,5S)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-carbaldehyde

Refernces