2-(AMinoMethyl)-1-Boc-piperidine

Base Information

• Chemical Name: 2-(AMinoMethyl)-1-Boc-piperidine
• CAS No.: 370-06-9
• Molecular Formula: C₈H₆F₃NO
• Molecular Weight: 189.137
• Hs Code.: 2933399990
• Mol file: 370-06-9.mol

Synonyms:2-Propanone,1,1,1-trifluoro-3-(2-pyridyl)- (8CI); NSC 80336

Chemical Property of 2-(AMinoMethyl)-1-Boc-piperidine

Chemical Property:

• Vapor Pressure: 0.489mmHg at 25°C
• Melting Point: 113-113.4 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 192.4°C at 760 mmHg
• PKA: 3.11±0.12(Predicted)
• Flash Point: 70.2°C
• PSA: 29.96000
• Density: 1.299g/cm³
• LogP: 1.75550

Purity/Quality:

99% ^*data from raw suppliers

1,1,1-Trifluoro-3-(pyridin-2-yl)propan-2-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(AMinoMethyl)-1-Boc-piperidine

There total 2 articles about 2-(AMinoMethyl)-1-Boc-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

α-picoline (109-06-8) + trifluoroacetic anhydride (407-25-0) → 1,1,1-trifluoro-3-(pyridin-2-yl)propan-2-one (370-06-9)

Guidance literature:

With pyridine; In benzene; for 24h; Ambient temperature;

DOI:10.3987/COM-98-8268

Reference yield:

2-pyridylmethyllithium (1749-29-7) + trifluoroacetic acid-methyl ester (431-47-0) → 1,1,1-trifluoro-3-(pyridin-2-yl)propan-2-one (370-06-9)

Guidance literature:

With diethyl ether; von Trifluoressigsaeure-methylester<0.5 Mol>;

DOI:10.1021/ja01618a075

upstream raw materials:

2-pyridylmethyllithium

trifluoroacetic acid-methyl ester

α-picoline

trifluoroacetic anhydride

Refernces

• 1、 Broese, Timo,Ehlers, Peter,Langer, Peter,von Langermann, Jan. "Chemoenzymatic Asymmetric Synthesis of Pyridine-Based α-Fluorinated Secondary Alcohols". . p. 3314 - 3318. Retrieved 2021/10/12.