1H-Pyrrolo[2,3-b]pyridine-3-acetonitrile

Base Information

• Chemical Name: 1H-Pyrrolo[2,3-b]pyridine-3-acetonitrile
• CAS No.: 4414-87-3
• Molecular Formula: C9H7 N3
• Molecular Weight: 157.175
• Hs Code.: 2933990090
• Mol file: 4414-87-3.mol

Synonyms:(1H-Pyrrolo[2,3-b]pyridin-3-yl)acetonitrile;3-(Cyanomethyl)pyrrolo[2,3-b]pyridine

Chemical Property of 1H-Pyrrolo[2,3-b]pyridine-3-acetonitrile

Chemical Property:

• Melting Point: 144 °C(Solv: benzene (71-43-2))
• Refractive Index: 1.684
• Boiling Point: °Cat760mmHg
• PKA: 6.95±0.20(Predicted)
• Flash Point: °C
• PSA: 52.47000
• Density: 1.295g/cm³
• LogP: 1.62898
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

2-(1H-Pyrrolo[2,3-b]pyridin-3-yl)acetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrrolo[2,3-b]pyridine-3-acetonitrile

There total 10 articles about 1H-Pyrrolo[2,3-b]pyridine-3-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

potassium cyanide + 7-azagramine (5654-92-2) → 1H-Pyrrolo[2,3-b]pyridin-3-yl-acetonitrile (4414-87-3)

Guidance literature:

With methyl iodide; In ethanol; water; at 20 ℃; for 16h;

DOI:10.1016/j.ejmech.2018.07.011

Reference yield: 56.0%

dimethyl-(1H-pyrrolo[2,3-b]-pyridinyl-methyl)-amine + dimethyl sulfate (77-78-1) → 1H-Pyrrolo[2,3-b]pyridin-3-yl-acetonitrile (4414-87-3)

Guidance literature:

In tetrahydrofuran; water;

Reference yield: 52.0%

sodium cyanide (773837-37-9) + 7-azagramine (5654-92-2) → 1H-Pyrrolo[2,3-b]pyridin-3-yl-acetonitrile (4414-87-3)

Guidance literature:

sodium cyanide; 7-azagramine; With acetic acid; In water; N,N-dimethyl-formamide; at 110 ℃; for 8h;

With potassium carbonate; In water; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2011.04.077

upstream raw materials:

7-azagramine

sodium cyanide

dimethyl sulfate

7-Azaindole

Downstream raw materials:

2-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-oxo-3-(3,4,5-trimethoxyphenyl)propanenitrile

5-amino-4-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazole

5-amino-N-methyl-4-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazole-1-carbothioamide

1-[5-amino-4-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazol-1-yl]ethanone

Refernces

• 1、 -. "COMPOUNDS AND USES THEREOF". . . Retrieved 2018/12/12.
• 2、 Labrière, Christophe,Talapatra, Sandeep K.,Thoret, Sylviane,Bougeret, Cécile,Kozielski, Frank,Guillou, Catherine. "New MKLP-2 inhibitors in the paprotrain series: Design, synthesis and biological evaluations". . p. 721 - 734. Retrieved 2016/02/09.