Technology Process of 5-ethyl-5-hydroxy-5H-dibenzo[a,d]cycloheptene
There total 1 articles about 5-ethyl-5-hydroxy-5H-dibenzo[a,d]cycloheptene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
ethylmagnesium bromide;
With
(trimethylsilyl)methylmagnesium chloride; lithium chloride; zinc(II) chloride;
In
tetrahydrofuran; diethyl ether;
at 20 ℃;
for 0.75h;
Inert atmosphere;
dibenzosuberenon;
In
tetrahydrofuran; diethyl ether;
at 0 ℃;
for 3h;
Inert atmosphere;
DOI:10.1021/jo100563p
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: acetyl chloride / 1.5 h / Reflux
2.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4 h / Reflux
3.1: water; acetone / 12 h / Reflux
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 4.33 h / Inert atmosphere; Reflux; Cooling with ice
5.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C
5.2: 4 h / 20 °C
6.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C
6.2: 4 h / 20 °C
With
N-Bromosuccinimide; lithium aluminium tetrahydride; sodium hydride; acetyl chloride; dibenzoyl peroxide;
In
tetrahydrofuran; tetrachloromethane; water; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: acetyl chloride / 1.5 h / Reflux
2.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4 h / Reflux
3.1: water; acetone / 12 h / Reflux
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 4.33 h / Inert atmosphere; Reflux; Cooling with ice
5.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C
5.2: 4 h / 20 °C
With
N-Bromosuccinimide; lithium aluminium tetrahydride; sodium hydride; acetyl chloride; dibenzoyl peroxide;
In
tetrahydrofuran; tetrachloromethane; water; N,N-dimethyl-formamide; acetone;