Benzoic acid, 4-cyano-, hydrazide (9CI)

Base Information

• Chemical Name: Benzoic acid, 4-cyano-, hydrazide (9CI)
• CAS No.: 43038-36-4
• Molecular Formula: C8H7 N3 O
• Molecular Weight: 161.163
• Hs Code.: 2928000090
• Mol file: 43038-36-4.mol

Synonyms:Benzoicacid, p-cyano-, hydrazide (6CI,7CI); 4-Cyanobenzoic acid hydrazide;4-Cyanobenzoic hydrazide; 4-Cyanobenzoylhydrazine; p-Cyanobenzoic acidhydrazide; p-Cyanobenzoyl hydrazide

Chemical Property of Benzoic acid, 4-cyano-, hydrazide (9CI)

Chemical Property:

• Refractive Index: 1.609
• PKA: 11?+-.0.10(Predicted)
• PSA: 78.91000
• Density: 1.28g/cm³
• LogP: 1.25298
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98% ^*data from raw suppliers

4-Cyanobenzohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 4-cyano-, hydrazide (9CI)

There total 10 articles about Benzoic acid, 4-cyano-, hydrazide (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-cyanobenzoic acid methyl ester (1129-35-7) → 4-cyanobenzohydrazide (43038-36-4)

Guidance literature:

With hydrazine hydrate; In methanol; for 48h;

DOI:10.1016/j.tetlet.2019.04.010

Reference yield: 90.0%

ethyl 4-cyanobenzoate (7153-22-2) → 4-cyanobenzohydrazide (43038-36-4)

Guidance literature:

With hydrazine hydrate; In ethanol; water; at 20 ℃; for 20.5h; Reflux;

Reference yield: 58.0%

4-cyanobenzoic acid methyl ester (1129-35-7) + hydrazine hydrate (7803-57-8,79785-97-0) → 4-cyanobenzohydrazide (43038-36-4)

Guidance literature:

In ethanol; at 80 ℃; for 1h;

upstream raw materials:

ethyl 4-cyanobenzoate

4-nitrophenyl 4-cyanobenzoate

4-cyanobenzoic acid methyl ester

4-cyanobenzoic Acid

Downstream raw materials:

3-(4-Cyano-phenyl)-5-[4-(2-methoxycarbonyl-ethyl)-phenyl]-1,2,4-triazole

Methyl N-[2-{2-(4-cyanophenyl)-1,3,4-oxadiazol-5-ylthio}-acetyl]-(S)-phenylalanine HCl salt

(Z)-2-[5-(4-cyanophenyl)-3-methyl-1,2,4-triazol-4-yl]-3-(1-naphthyl)-2-propeonic acid

4-cyano-[N'-(benzofuroxan-5-yl)methylene]benzohydrazide

Refernces

• 1、 ?wiatkowski, Marcin,Kudelko, Agnieszka,Maj, Anna. "Novel Conjugated s-Tetrazine Derivatives Bearing a 4H-1,2,4-Triazole Scaffold: Synthesis and Luminescent Properties". . . Retrieved 2022/01/20.
• 2、 Li, Yitao,Yao, Wenqiang,Lin, Jian,Gao, Guoliang,Huang, Chang,Wu, Yang. "Design, synthesis, and biological evaluation of phenyloxadiazole derivatives as potential antifungal agents against phytopathogenic fungi". . p. 121 - 135. Retrieved 2021/01/05.