Technology Process of D-13β-Ethyl-11-methylenegon-4-en-17α-ol
There total 1 articles about D-13β-Ethyl-11-methylenegon-4-en-17α-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 7 steps
1: 94 percent / Jones' reagent / acetone / 0.25 h / -15 - -10 °C
2: 79 percent / HC(OEt)3, p-TsOH*H2O / CH2Cl2 / 7 h / Heating
3: 88 percent / benzene; diethyl ether / 3 h / 10 - 15 °C
4: 74 percent / p-TsOH*H2O / formic acid / 7 h / 50 - 60 °C
5: 98 percent / BF3*Et2O / methanol / 2.5 h / 0 - 5 °C
6: 100 percent / NaBH4 / methanol / 2 h / Ambient temperature
7: 94 percent / Na, liq. NH3 / tetrahydrofuran / 0.5 h / -50 - -45 °C
With
sodium tetrahydroborate; jones' reagent; boron trifluoride diethyl etherate; ammonia; sodium; toluene-4-sulfonic acid; orthoformic acid triethyl ester;
In
tetrahydrofuran; methanol; formic acid; diethyl ether; dichloromethane; acetone; benzene;
DOI:10.1080/00304949709355234
- Guidance literature:
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Multi-step reaction with 2 steps
1: 82 percent / Jones' reagent / acetone / 0.25 h / -15 - -10 °C
2: 72 percent / n-C4H9Br, Li / tetrahydrofuran; diethyl ether / 1.) -10 deg C, 2 h; -5 deg C, 3 h, 2.) -5 deg C, 3 h
With
1-bromo-butane; jones' reagent; lithium;
In
tetrahydrofuran; diethyl ether; acetone;
DOI:10.1080/00304949709355234