(-)-(S)-α-methyl-N-(phenylmethyl)benzenepropanamine

Base Information

• Chemical Name: (-)-(S)-α-methyl-N-(phenylmethyl)benzenepropanamine
• CAS No.: 75659-04-0
• Molecular Formula: C₁₇H₂₁N
• Molecular Weight: 239.36
• Mol file: 75659-04-0.mol

Synonyms:(-)-(S)-α-methyl-N-(phenylmethyl)benzenepropanamine

Chemical Property of (-)-(S)-α-methyl-N-(phenylmethyl)benzenepropanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-(S)-α-methyl-N-(phenylmethyl)benzenepropanamine

There total 11 articles about (-)-(S)-α-methyl-N-(phenylmethyl)benzenepropanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(R(a),R)-4-(1-methyl-3-phenylpropoxy)dinaphtho[2,1-d:1'2'-f][1,3,2]dioxaphosphepin-4-selenide + benzylamine (100-46-9) → (-)-(S)-α-methyl-N-(phenylmethyl)benzenepropanamine (75659-04-0)

Guidance literature:

(R(a),R)-4-(1-methyl-3-phenylpropoxy)dinaphtho[2,1-d:1'2'-f][1,3,2]dioxaphosphepin-4-selenide; benzylamine; In tetrahydrofuran; for 15h; Heating;

With sodium hydroxide; In tetrahydrofuran; for 1h; Heating;

DOI:10.1021/ja060308b

Reference yield:

N-benzyl-1-methyl-3-phenylpropylamine (68164-04-5) → (-)-(S)-α-methyl-N-(phenylmethyl)benzenepropanamine (75659-04-0)

Guidance literature:

DOI:10.1021/jm00353a017

Reference yield:

((S)-1-Methyl-3-phenyl-propyl)-[1-phenyl-meth-(E)-ylidene]-amine (4187-36-4) → (-)-(S)-α-methyl-N-(phenylmethyl)benzenepropanamine (75659-04-0)

Guidance literature:

With hydrogen; PtO/C; In ethanol; for 16h; under 760 Torr; Ambient temperature;

DOI:10.1021/jm00348a013

upstream raw materials:

N-benzyl-1-methyl-3-phenylpropylamine

((S)-1-Methyl-3-phenyl-propyl)-[1-phenyl-meth-(E)-ylidene]-amine

benzylamine

1-phenyl-3-butanol

Downstream raw materials:

(S)-2-hydroxy-5-<acetyl>benzamide

*)>-2-hydroxy-5-<1-hydroxy-2-<(1-methyl-3-phenylpropyl)amino>ethyl>benzamide

*)>-2-hydroxy-5-<1-hydroxy-2-<(1-methyl-3-phenylpropyl)amino>ethyl>benzamide

(-)-2-hydroxy-5-<(R)-1-hydroxy-2-<(S)-(1-methyl-3-phenylpropyl)amino>ethyl>benzamide hydrochloride

Refernces

• 1、 Reznichenko, Alexander L.,Hultzsch, Kai C.. "C1-symmetric rare-earth-metal aminodiolate complexes for intra- and intermolecular asymmetric hydroamination of alkenes". . p. 1394 - 1408. Retrieved 2013/05/21.
• 2、 Reznichenko, Alexander L.,Nguyen, Hiep N.,Hultzsch, Kai C.. "Asymmetric intermolecular hydroamination of unactivated alkenes with simple amines". supporting information; experimental part. p. 8984 - 8987. Retrieved 2011/02/21.