6-Aminonicotinohydrazide

Base Information

• Chemical Name: 6-Aminonicotinohydrazide
• CAS No.: 42596-56-5
• Molecular Formula: C6H8N4O
• Molecular Weight: 152.156
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID30376902
• Wikidata: Q82165819
• Mol file: 42596-56-5.mol

Synonyms:6-aminonicotinohydrazide;42596-56-5;6-aminopyridine-3-carbohydrazide;6-Amino-nicotinohydrazide;SCHEMBL8483127;DTXSID30376902;MFCD03844845;AKOS005069301;SB86098;CS-0317842;FT-0679966;6-Imino-1,6-dihydropyridine-3-carbohydrazide;F81460;EN300-6454843;A872852;10W-0706;J-518251

Chemical Property of 6-Aminonicotinohydrazide

Chemical Property:

• Melting Point: 228-232 °C
• Refractive Index: 1.651
• PSA: 94.03000
• Density: 1.352 g/cm³
• LogP: 0.93970
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 152.06981089
• Heavy Atom Count: 11
• Complexity: 150

Purity/Quality:

98%min ^*data from raw suppliers

6-Aminonicotinohydrazide >95% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC=C1C(=O)NN)N

Technology Process of 6-Aminonicotinohydrazide

There total 2 articles about 6-Aminonicotinohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl-6-amino-nicotinate (39658-41-8) → 6-amino-nicotinic acid hydrazide (42596-56-5)

Guidance literature:

With hydrazine hydrate;

Reference yield:

6-aminonicotinic acid (3167-49-5) → 6-amino-nicotinic acid hydrazide (42596-56-5)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl

2: N₂H₄+H₂O

With hydrogenchloride; hydrazine hydrate;

Reference yield: 75.0%

6-amino-nicotinic acid hydrazide (42596-56-5) + (1'R,2'S,3'R)-2-acetyl-4(5)-(1',2',3',4'-tetrahydroxy-1'-butyl)imidazole (94944-70-4) → (E)-6-amino-N'-(1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethylidene)nicotinohydrazide

Guidance literature:

hydrogenchloride; In ethanol; water; at 55 ℃; for 48h;

upstream raw materials:

ethyl-6-amino-nicotinate

6-aminonicotinic acid

Downstream raw materials:

5-(5-(benzylthio)-1,3,4-oxadiazol-2-yl)pyridin-2-amine

Refernces

• 1、 Liu, Kai,Lu, Xiang,Zhang, Hong-Jia,Sun, Juan,Zhu, Hai-Liang. "Synthesis, molecular modeling and biological evaluation of 2-(benzylthio)-5-aryloxadiazole derivatives as anti-tumor agents". experimental part. p. 473 - 478. Retrieved 2012/03/13.