2-Pyridinyl sulphide

Base Information

• Chemical Name: 2-Pyridinyl sulphide
• CAS No.: 4262-06-0
• Molecular Formula: C10H8N2S
• Molecular Weight: 188.253
• Hs Code.: 2933399090
• Mol file: 4262-06-0.mol

Synonyms:Pyridine,2,2'-thiodi- (7CI,8CI);2,2'-Dipyridyl sulfide;2,2'-Thiobis[pyridine];2,2'-Thiodipyridine;Di-2-pyridyl sulfide;

Chemical Property of 2-Pyridinyl sulphide

Chemical Property:

• Vapor Pressure: 0.000104mmHg at 25°C
• Refractive Index: 1.653
• Boiling Point: 348 °C at 760 mmHg
• Flash Point: 164.3 °C
• PSA: 51.08000
• Density: 1.25 g/cm³
• LogP: 2.62780

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-PYRIDINYL SULFIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyridinyl sulphide

There total 6 articles about 2-Pyridinyl sulphide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-chloropyridine (109-09-1) + benzyl alcohol (100-51-6,185532-71-2) → di-2-pyridyl sulfide (4262-06-0) + 2-(benzylthio)pyridine (51290-79-0)

Guidance literature:

With Sodium thiosulfate pentahydrate; In neat (no solvent); at 120 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.joc.9b01670

Reference yield: 56.0%

2-bromo-pyridine (109-04-6) → di-2-pyridyl sulfide (4262-06-0) + 2,2'-dipyridyldisulphide (2127-03-9)

Guidance literature:

With sodium sulfide; chloro-trimethyl-silane; In various solvent(s); at 160 ℃;

DOI:10.1021/jo00069a046

Reference yield:

2-bromo-pyridine (109-04-6) → 2-Sulfanylpyridine (2637-34-5,73018-10-7) + di-2-pyridyl sulfide (4262-06-0)

Guidance literature:

With water; thiourea; benzyl alcohol; In neat (no solvent); at 100 ℃; for 24h; Sealed tube;

DOI:10.1002/adsc.201700227

upstream raw materials:

2-bromo-pyridine

2-chloropyridine

methyl iodide

benzyl alcohol

Downstream raw materials:

{Rh(C₈H₁₂)((C₅H₄N)2S)}⁽¹⁺⁾*{B(C₆H₅)4}^(1-)={Rh(C₈H₁₂)((C₅H₄N)2S)}{B(C₆H₅)4}

{Rh(CO)(As(C₆H₅)3)((C₅H₄N)2S)}⁽¹⁺⁾*BF₄^(1-)={Rh(CO)(As(C₆H₅)3)((C₅H₄N)2S)}{BF₄}

C₂₆H₃₂Cl₂N₂Rh₂S

2-(p-tolylthio)pyridine

Refernces

• 1、 Ma, Xiantao,Yu, Jing,Yan, Ran,Yan, Mengli,Xu, Qing. "Promoting Effect of Crystal Water Leading to Catalyst-Free Synthesis of Heteroaryl Thioether from Heteroaryl Chloride, Sodium Thiosulfate Pentahydrate, and Alcohol". . p. 11294 - 11300. Retrieved 2019/09/12.
• 2、 Chen, Hsing-Ying,Peng, Wei-Te,Lee, Ying-Hsien,Chang, Yu-Lun,Chen, Yen-Jen,Lai, Yi-Chun,Jheng, Nai-Yuan,Chen, Hsuan-Ying. "Use of base control to provide high selectivity between diaryl thioether and diaryl disulfide for C-S coupling reactions of aryl halides and sulfur and a mechanistic study". supporting information. p. 5514 - 5522. Retrieved 2013/11/06.