8-(benzoyloxy)-6-hydroxyoctanoic acid

Base Information

• Chemical Name: 8-(benzoyloxy)-6-hydroxyoctanoic acid
• CAS No.: 860021-50-7
• Molecular Formula: C₁₅H₂₀O₅
• Molecular Weight: 280.321
• Mol file: 860021-50-7.mol

Synonyms:8-(benzoyloxy)-6-hydroxyoctanoic acid

Chemical Property of 8-(benzoyloxy)-6-hydroxyoctanoic acid

Chemical Property:

Purity/Quality:

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Technology Process of 8-(benzoyloxy)-6-hydroxyoctanoic acid

There total 1 articles about 8-(benzoyloxy)-6-hydroxyoctanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-cyclohex-1-en-1-ylethyl benzoate (860021-48-3) → 8-(benzoyloxy)-6-hydroxyoctanoic acid (860021-50-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: O₃ / CH₂Cl₂ / -78 °C

1.2: 85 percent / Jones reagent / acetone / 0 °C

2.1: 90 percent / NaBH₄ / methanol / 0 °C

With sodium tetrahydroborate; ozone; In methanol; dichloromethane; 1.2: Jones oxidation;

DOI:10.1055/s-2005-861867

Reference yield:

8-(benzoyloxy)-6-hydroxyoctanoic acid (860021-50-7) → Thioctic acid (1077-28-7,62-46-4)

Guidance literature:

Multi-step reaction with 5 steps

1: diethyl ether

2: 340 mg / NaOMe / methanol

3: Et₃N / CH₂Cl₂ / 0 °C

4: 257 mg / Na₂S*H₂O; sulfur / dimethylformamide / 24 h / 80 °C

5: 70 percent / aq. KOH / methanol / 24 h / 20 °C

With sodium sulfide; potassium hydroxide; sodium methylate; sulfur; triethylamine; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1055/s-2005-861867

Reference yield:

8-(benzoyloxy)-6-hydroxyoctanoic acid (860021-50-7) + diazomethane (186581-53-3,908094-01-9,334-88-3) → 8-(benzoyloxy)-6-hydroxyoctanoic acid methyl ester

Guidance literature:

In diethyl ether;

DOI:10.1055/s-2005-861867

upstream raw materials:

2-cyclohex-1-en-1-ylethyl benzoate

Downstream raw materials:

Thioctic acid

Refernces