(E)-N'-((4-methylphenyl)sulfonyl)-N,N-dipropylformimidamide

Base Information

• Chemical Name: (E)-N'-((4-methylphenyl)sulfonyl)-N,N-dipropylformimidamide
• CAS No.: 1204768-66-0
• Molecular Formula: C₁₄H₂₂N₂O₂S
• Molecular Weight: 282.407
• Mol file: 1204768-66-0.mol

Synonyms:(E)-N'-((4-methylphenyl)sulfonyl)-N,N-dipropylformimidamide

Chemical Property of (E)-N'-((4-methylphenyl)sulfonyl)-N,N-dipropylformimidamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N'-((4-methylphenyl)sulfonyl)-N,N-dipropylformimidamide

There total 3 articles about (E)-N'-((4-methylphenyl)sulfonyl)-N,N-dipropylformimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

tri-n-propylamine (102-69-2) + 4-toluenesulfonyl azide (941-55-9) → (E)-N'-((4-methylphenyl)sulfonyl)-N,N-dipropylformimidamide (1204768-66-0)

Guidance literature:

With tert-butylammonium hexafluorophosphate(V); In acetonitrile; at 25 ℃; for 3h; Electrolysis;

DOI:10.1039/c1cc10871a

Reference yield: 57.0%

4-toluenesulfonyl azide (941-55-9) + di-n-propylamine (142-84-7) → (E)-N'-((4-methylphenyl)sulfonyl)-N,N-dipropylformimidamide (1204768-66-0)

Guidance literature:

With tert.-butylhydroperoxide; In water; 1,2-dichloro-ethane; at 80 ℃; for 5h;

DOI:10.1016/j.tet.2018.03.074

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → (E)-N'-((4-methylphenyl)sulfonyl)-N,N-dipropylformimidamide (1204768-66-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / acetone; water / 2 h / 20 °C / Inert atmosphere; Sealed tube

2: eosin Y disodium salt; sodium carbonate / acetonitrile / 3 h / 20 °C / Irradiation; Sealed tube; Green chemistry

With sodium azide; sodium carbonate; eosin Y disodium salt; In water; acetone; acetonitrile;

DOI:10.1021/acs.orglett.9b00786

upstream raw materials:

tri-n-propylamine

4-toluenesulfonyl azide

di-n-propylamine

p-toluenesulfonyl chloride

Refernces

• 1、 Ding, Rui,Chen, Hui,Xu, Yan-Li,Tang, Hai-Tao,Chen, Yan-Yan,Pan, Ying-Ming. "Photoinduced Cascade Reaction of Tertiary Amines with Sulfonyl Azides: Synthesis of Amidine Derivatives". supporting information. p. 3656 - 3660. Retrieved 2019/07/10.
• 2、 Chen, Ming,Jian, Yong,Xia, Wujiong,Yang, Chao. "Nitroacenaphthene as a New Photocatalyst for the Synthesis of Sulfonyl Amidines". . p. 4425 - 4433. Retrieved 2019/11/21.