Technology Process of Carbamic acid, [[(2R,4S)-4-hydroxy-2-pyrrolidinyl]methyl]-, 1,1-dimethylethyl
There total 8 articles about Carbamic acid, [[(2R,4S)-4-hydroxy-2-pyrrolidinyl]methyl]-, 1,1-dimethylethyl which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
methanol;
at 20 ℃;
for 7h;
under 3102.97 Torr;
DOI:10.1039/b413542c
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 88 percent / LiCl; NaBH4 / tetrahydrofuran; ethanol / 20 °C
2: 75 percent / pyridine / 8 h / 20 °C
3: 96 percent / NaN3 / dimethylformamide / 8 h / 55 °C
4: H2 / Raney Ni / methanol / 3.5 h / 20 °C / 1810.02 - 2068.59 Torr
5: 76 percent / Et3N / dimethylsulfoxide / 8 h / 50 °C
6: H2 / Pd/C / methanol / 7 h / 20 °C / 3102.89 Torr
With
pyridine; sodium tetrahydroborate; sodium azide; hydrogen; triethylamine; lithium chloride;
palladium on activated charcoal; nickel;
In
tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2005.12.002
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 75 percent / pyridine / 8 h / 20 °C
2: 96 percent / NaN3 / dimethylformamide / 8 h / 55 °C
3: H2 / Raney Ni / methanol / 3.5 h / 20 °C / 1810.02 - 2068.59 Torr
4: 76 percent / Et3N / dimethylsulfoxide / 8 h / 50 °C
5: H2 / Pd/C / methanol / 7 h / 20 °C / 3102.89 Torr
With
pyridine; sodium azide; hydrogen; triethylamine;
palladium on activated charcoal; nickel;
In
methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2005.12.002
