dimethyl-{2-[3-(1-pyridin-2-yl-propyl)-inden-2-yl]-ethyl}-amine

Base Information

• Chemical Name: dimethyl-{2-[3-(1-pyridin-2-yl-propyl)-inden-2-yl]-ethyl}-amine
• CAS No.: 98131-72-7
• Molecular Formula: C₂₁H₂₆N₂
• Molecular Weight: 306.451
• Mol file: 98131-72-7.mol

Synonyms:dimethyl-{2-[3-(1-pyridin-2-yl-propyl)-inden-2-yl]-ethyl}-amine

Chemical Property of dimethyl-{2-[3-(1-pyridin-2-yl-propyl)-inden-2-yl]-ethyl}-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of dimethyl-{2-[3-(1-pyridin-2-yl-propyl)-inden-2-yl]-ethyl}-amine

There total 2 articles about dimethyl-{2-[3-(1-pyridin-2-yl-propyl)-inden-2-yl]-ethyl}-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-propylpyridine (622-39-9) + 2-[2-(dimethylamino)ethyl]indan-1-one (3409-21-0) → dimethyl-{2-[3-(1-pyridin-2-yl-propyl)-inden-2-yl]-ethyl}-amine (98131-72-7)

Guidance literature:

2-propylpyridine; With n-butyllithium; In diethyl ether; at -78 ℃; for 2h;

2-[2-(dimethylamino)ethyl]indan-1-one; In diethyl ether; at 20 ℃;

With hydrogenchloride; for 1h; Further stages.; Heating;

DOI:10.1021/jm020895l

Reference yield:

2-benzyl-2-[2-(dimethylamino)ethyl]malonic acid diethyl ester (1805-03-4) → dimethyl-{2-[3-(1-pyridin-2-yl-propyl)-inden-2-yl]-ethyl}-amine (98131-72-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 77 percent / aq. NaOH / ethanol / 4 h / Heating

2.1: 41 percent / polyphosphoric acid / 0.33 h / 140 - 150 °C

3.1: BuLi / diethyl ether / 2 h / -78 °C

3.2: diethyl ether / 20 °C

3.3: aq. HCl / 1 h / Heating

With sodium hydroxide; n-butyllithium; PPA; In diethyl ether; ethanol;

DOI:10.1021/jm020895l

upstream raw materials:

2-propylpyridine

2-[2-(dimethylamino)ethyl]indan-1-one

2-benzyl-2-[2-(dimethylamino)ethyl]malonic acid diethyl ester

Refernces