4a-methyl-5,6,7,8-tetrahydronaphthalen-2(4aH)-one

Base Information

• Chemical Name: 4a-methyl-5,6,7,8-tetrahydronaphthalen-2(4aH)-one
• CAS No.: 703-02-6
• Molecular Formula: C₁₁H₁₄O
• Molecular Weight: 162.232
• Mol file: 703-02-6.mol

Synonyms:(?à)-4,4a,5,6,7,8-Hexahydro-4a-methyl-2(3H)-naphthalenone;5,6,7,8-Tetrahydro-4a-methylnaphthalen-2(4aH)-one; NSC 239313

Chemical Property of 4a-methyl-5,6,7,8-tetrahydronaphthalen-2(4aH)-one

Chemical Property:

• Vapor Pressure: 0.00606mmHg at 25°C
• Boiling Point: 272.5°Cat760mmHg
• Flash Point: 112.4°C
• Density: 1.03g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4a-methyl-5,6,7,8-tetrahydronaphthalen-2(4aH)-one

There total 9 articles about 4a-methyl-5,6,7,8-tetrahydronaphthalen-2(4aH)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-Methyl-2-(3'-oxo-1'-butenyl)cyclohexanone (83181-15-1) → 4a-methyl-5,6,7,8-tetrahydro-2(4aH)-naphthalenone (703-02-6)

Guidance literature:

With potassium hydroxide; In methanol; for 7h; Heating;

DOI:10.1055/s-1982-29974

Reference yield: 43.0%

4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one (826-56-2) → 4a-methyl-5,6,7,8-tetrahydro-2(4aH)-naphthalenone (703-02-6)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In toluene; for 4h; Heating;

DOI:10.1021/jo00018a028

Reference yield:

acetone (67-64-1) → 4a-methyl-5,6,7,8-tetrahydro-2(4aH)-naphthalenone (703-02-6)

Guidance literature:

With piperidine; acetic acid; Kochen des Reaktionsprodukts in Methanol unter Zusatz von wss. Kalilauge;

DOI:10.1021/ja01157a129

upstream raw materials:

4a-methyl-octahydro-naphthalen-2-one

4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one

4,4a,5,6,7,8-hexahydro-4a-methyl-4-carboxy-2(3H)-naphthalenone

2-Methyl-2-(3'-oxo-1'-butenyl)cyclohexanone

Downstream raw materials:

1-Hydroxy-4-methyl-5,6,7,8-tetrahydro-naphthalin

5,6,7,8-tetrahydro-4-methyl-2-naphthalenol

Refernces

• 1、 Caine et al.. "". . p. 967. Retrieved 1973.
• 2、 Thangaraj, K.,Srinivasan, P. C.,Swaminathan, S.. "A Facile Annulation Sequence". . p. 855 - 857. Retrieved 2007/10/02.