2-(4-(1-adaMantane)phenoxy)ethyl acetate

Base Information

• Chemical Name: 2-(4-(1-adaMantane)phenoxy)ethyl acetate
• CAS No.: 52804-25-8
• Molecular Formula: C₂₀H₂₆O₃
• Molecular Weight: 314.425
• Mol file: 52804-25-8.mol

Synonyms:(4-adamantyl-1-yl-phenoxy) acetic acid ethyl ester

Chemical Property of 2-(4-(1-adaMantane)phenoxy)ethyl acetate

Chemical Property:

• Melting Point: 86.6-88.6 °C
• Boiling Point: 422.5±28.0 °C(Predicted)
• Density: 1.141±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-(4-((3r,5r,7r)-adamantan-1-yl)phenoxy)acetate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(1-adaMantane)phenoxy)ethyl acetate

There total 4 articles about 2-(4-(1-adaMantane)phenoxy)ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-adamantylphenol (29799-07-3) + chloroacetic acid ethyl ester (105-39-5) → (4-adamantyl-1-yl-phenoxy) acetic acid ethyl ester (52804-25-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2007.09.005

Reference yield:

1-Adamantyl bromide (768-90-1) → (4-adamantyl-1-yl-phenoxy) acetic acid ethyl ester (52804-25-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 15 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.bioorg.2021.104779

Reference yield:

phenol (108-95-2,27073-41-2) → (4-adamantyl-1-yl-phenoxy) acetic acid ethyl ester (52804-25-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 15 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.bioorg.2021.104779

upstream raw materials:

4-adamantylphenol

chloroacetic acid ethyl ester

1-Adamantyl bromide

phenol

Downstream raw materials:

(4-adamantan-1-yl-phenoxy)acetic acid

C₃₀H₃₇N₃O₅

C₃₀H₃₇N₃O₄

C₂₇H₃₂N₂O₅

Refernces

• 1、 Naik, Ravi,Ban, Hyun Seung,Jang, Kyusic,Kim, Inhyub,Xu, Xuezhen,Harmalkar, Dipesh,Shin, Seong-Ah,Kim, Minkyoung,Kim, Bo-Kyung,Park, Jaehyung,Ku, Bonsu,Oh, Sujin,Won, Misun,Lee, Kyeong. "Methyl 3-(3-(4-(2,4,4-Trimethylpentan-2-yl)phenoxy)-propanamido)benzoate as a Novel and Dual Malate Dehydrogenase (MDH) 1/2 Inhibitor Targeting Cancer Metabolism". . p. 8631 - 8646. Retrieved 2017/11/03.
• 2、 Lee, Kyeong,Goo, Ja-Il,Jung, Hwa Young,Kim, Minkyoung,Boovanahalli, Shanthaveerappa K.,Park, Hye Ran,Kim, Mun-Ock,Kim, Dong-Hyun,Lee, Hyun Sun,Choi, Yongseok. "Discovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors". supporting information. p. 7456 - 7460. Retrieved 2013/02/22.