C₁₅H₁₅ClN₂O

Base Information

• Chemical Name: C₁₅H₁₅ClN₂O
• CAS No.: 1356397-47-1
• Molecular Formula: C₁₅H₁₅ClN₂O
• Molecular Weight: 274.75
• Mol file: 1356397-47-1.mol

Synonyms:C₁₅H₁₅ClN₂O

Chemical Property of C₁₅H₁₅ClN₂O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of C₁₅H₁₅ClN₂O

There total 7 articles about C₁₅H₁₅ClN₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(EZ)-2-(2-ethoxyvinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1360111-87-0) + C11H8BrClN2 (911113-60-5) → C15H15ClN2O (1356397-47-1)

Guidance literature:

With lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide; at 70 ℃; for 18h; Product distribution / selectivity;

Reference yield:

(EZ)-2-(2-ethoxyvinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1360111-87-0) + C11H8ClIN2 (1356397-46-0) → C15H15ClN2O (1356397-47-1)

Guidance literature:

With lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide; at 70 ℃; for 18h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

C11H8ClIN2 (1356397-46-0) + catechol vinylboronate → C15H15ClN2O (1356397-47-1)

Guidance literature:

With lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 80 ℃; for 24h; Product distribution / selectivity;

upstream raw materials:

5-bromo-2-pyridylamine

4-Chlorophenylboronic acid

5-(4-chlorophenyl)pyridin-2-ylamine

(EZ)-2-(2-ethoxyvinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Downstream raw materials:

5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine

vemurafenib

Refernces

• 1、 -. "Novel Processes for the manufacture of Propane-1-sulfonic acid -amide". . . Retrieved 2012/02/03.