Technology Process of 3-methyl-3-phenylindoline
There total 12 articles about 3-methyl-3-phenylindoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-Phenylpropanal; phenylhydrazine;
With
acetic acid;
at 80 ℃;
With
sodium tris(acetoxy)borohydride;
In
1,2-dichloro-ethane;
at 20 ℃;
Cooling;
DOI:10.1016/j.tet.2009.11.080
- Guidance literature:
-
3-Methylindole; diphenyliodonium tetrafluoroborate;
With
N,N,N′,N′-tetramethyl-N″-tert-butylguanidine;
In
dichloromethane; toluene;
Inert atmosphere;
With
sodium cyanoborohydride;
In
methanol; dichloromethane;
for 0.5h;
With
silica gel;
In
methanol; dichloromethane;
for 0.5h;
DOI:10.1016/j.tet.2008.09.028
- Guidance literature:
-
3-Methylindole; phenyl 1,1,2,2,3,3,4,4,4-nonafluoro-1-butanesulfonate;
With
Cy-DHTP*HBF4; palladium diacetate; lithium tert-butoxide;
In
toluene;
at 110 ℃;
for 12h;
Sealed tube;
Inert atmosphere;
With
sodium cyanoborohydride;
In
methanol; dichloromethane;
at 20 ℃;
Inert atmosphere;
DOI:10.1021/acs.joc.0c01494
