Technology Process of (1Z,3Z)-5-(Methoxymethoxy)-7-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-(dimethylphenylsilyl)-2-<3,4-(methylenedioxy)phenyl>-1,3-heptadiene
There total 9 articles about (1Z,3Z)-5-(Methoxymethoxy)-7-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1-(dimethylphenylsilyl)-2-<3,4-(methylenedioxy)phenyl>-1,3-heptadiene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 87 percent / n-BuLi, I2 / tetrahydrofuran; hexane / 1.) -90 to -50 deg C, 15 min, 2.) -78 deg C to r.t.
2: 100 percent / CuI, Et3N / (Ph3As)2PdCl2 / 1.5 h / Ambient temperature
3: 92 percent / K2CO3 / methanol / 2 h / Ambient temperature
With
copper(l) iodide; n-butyllithium; iodine; potassium carbonate; triethylamine;
PdCl2(AsPh3)2;
In
tetrahydrofuran; methanol; hexane;
DOI:10.1021/jo00098a026
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 100 percent / CuI, Et3N / (Ph3As)2PdCl2 / 1.5 h / Ambient temperature
2: 92 percent / K2CO3 / methanol / 2 h / Ambient temperature
With
copper(l) iodide; potassium carbonate; triethylamine;
PdCl2(AsPh3)2;
In
methanol;
DOI:10.1021/jo00098a026
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 76 percent / TMEDA, n-BuLi / hexane; tetrahydrofuran / 0.67 h / -78 °C
2: 87 percent / diisopropylethylamine / CH2Cl2 / 18 h / 40 °C
3: 95 percent / n-BuLi, I2 / 1.) Et2O, hexane, -78 deg C, 15 min, 2.) THF, -78 deg C to r.t.
4: 95 percent / glacial acetic acid, dipotassium azodicarboxylate / methanol / 20 h / Ambient temperature
With
n-butyllithium; N,N,N,N,-tetramethylethylenediamine; iodine; potassium diazodicarboxylate; acetic acid; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/jo00098a026
