Multi-step reaction with 8 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.33 h / 0 °C / Inert atmosphere
2.1: trifluorormethanesulfonic acid / dichloromethane; cyclohexane / 0 - 20 °C / Inert atmosphere
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.58 h / 0 - 20 °C / Inert atmosphere
4.1: ethanol; magnesium; mercury dichloride / 4 h / 0 - 20 °C / Inert atmosphere
5.1: boron trifluoride diethyl etherate / dichloromethane / 39 h / 0 - 20 °C / Inert atmosphere; Molecular sieve
5.2: 0.17 h / Cooling with ice
6.1: ethanol; potassium carbonate / acetonitrile / 12 h / 20 °C / Inert atmosphere
7.1: n-butyllithium / tetrahydrofuran; hexanes / 1 h / -10 °C / Inert atmosphere
7.2: 4 h / -10 - 20 °C / Inert atmosphere
8.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 12 h / Inert atmosphere; Reflux
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; n-butyllithium; ethanol; trifluorormethanesulfonic acid; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; potassium carbonate; magnesium; 3-chloro-benzenecarboperoxoic acid; mercury dichloride;
In
tetrahydrofuran; hexanes; dichloromethane; cyclohexane; acetonitrile;
DOI:10.1016/j.tet.2011.07.079