2-Methyl-4,6-diphenylnicotinonitrile

Base Information

• Chemical Name: 2-Methyl-4,6-diphenylnicotinonitrile
• CAS No.: 94211-96-8
• Molecular Formula: C₁₉H₁₄N₂
• Molecular Weight: 270.334
• Mol file: 94211-96-8.mol

Synonyms:2-methyl-4,6-diphenylpyridine-3-carbonitrile

Chemical Property of 2-Methyl-4,6-diphenylnicotinonitrile

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

2-Methyl-4,6-diphenylnicotinonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Methyl-4,6-diphenylnicotinonitrile

There total 14 articles about 2-Methyl-4,6-diphenylnicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4,6-diphenyl-2-methoxypyridine-3-carbonitrile (60847-68-9) + methyllithium (917-54-4) → 2-methyl-4,6-diphenylpyridine-3-carbonitrile (94211-96-8)

Guidance literature:

4,6-diphenyl-2-methoxypyridine-3-carbonitrile; methyllithium; With boron trifluoride diethyl etherate; copper(l) cyanide; lithium chloride; In tetrahydrofuran; at -78 ℃; for 0.5h;

In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1016/j.tetlet.2007.02.096

Reference yield: 93.0%

1,3-diphenyl-propen-3-one (614-47-1) + 3-iminobutyronitrile (1118-60-1) → 2-methyl-4,6-diphenylpyridine-3-carbonitrile (94211-96-8)

Guidance literature:

With potassium tert-butylate; In acetonitrile; for 0.25h; Ambient temperature; Irradiation;

DOI:10.1246/bcsj.61.2199

Reference yield: 72.0%

3-Aminocrotononitrile (1118-61-2) + benzalacetophenone (94-41-7) → 2-methyl-4,6-diphenylpyridine-3-carbonitrile (94211-96-8)

Guidance literature:

With sodium ethanolate; In ethanol; Reflux;

DOI:10.1007/s10593-017-2165-y

upstream raw materials:

3-Aminocrotononitrile

sodium ethanolate

benzalacetophenone

1,3-diphenyl-propen-3-one

Downstream raw materials:

1,3-dimethyl-4,6-diphenyl-1H-pyrazolo[3,4-b]pyridine

2-methyl-4,6-diphenylpyridine-3-carboxamide

2-methyl-4,6-diphenyl-nicotinic acid

Refernces

• 1、 Abdel-Aziz, Alaa A.-M.. "Lewis acid-promoted direct substitution of 2-methoxy-3-cyanopyridines by organo cuprates. Part 3: Facile preparation of nicotinamide and nicotinic acid derivatives". . p. 2861 - 2865. Retrieved 2007/10/03.
• 2、 Hojahmat, Marhaba,Konakahara, Takeo,Tamura, Sanae. "A novel synthesis of 2,3-dialkylpyridine derivatives from dialkyl-N- silylimines and 1,3-diaryl-2-propen-1-one or (E)-1,1,1-trifluoro-4-phenyl-3- buten-2-one". . p. 629 - 636. Retrieved 2007/10/03.