3-Pyridinecarbonyl chloride, 6-cyano- (9CI)

Base Information

• Chemical Name: 3-Pyridinecarbonyl chloride, 6-cyano- (9CI)
• CAS No.: 313350-44-6
• Molecular Formula: C7H3 Cl N2 O
• Molecular Weight: 166.56452
• Mol file: 313350-44-6.mol

Synonyms:3-Pyridinecarbonyl chloride, 6-cyano- (9CI)

Chemical Property of 3-Pyridinecarbonyl chloride, 6-cyano- (9CI)

Chemical Property:

• PSA: 53.75000
• LogP: 1.33228

Purity/Quality:

99%min ^*data from raw suppliers

3-Pyridinecarbonylchloride,6-cyano-(9ci) 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarbonyl chloride, 6-cyano- (9CI)

There total 2 articles about 3-Pyridinecarbonyl chloride, 6-cyano- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

6-cyanonicotinic acid (70165-31-0) → 6-cyano-nicotinoyl chloride (313350-44-6)

Guidance literature:

With thionyl chloride;

DOI:10.1039/b401919a

Reference yield:

Nicotinic acid N-oxide (2398-81-4) → 6-cyano-nicotinoyl chloride (313350-44-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / Me₃SiCl

2: 70 percent / SOCl₂

With chloro-trimethyl-silane; thionyl chloride;

DOI:10.1039/b401919a

Reference yield:

5-ethyl-2-fluoro-4-[3-(1,4,5,6,7,8-hexahydro-imidazo[4,5-d]azepin-2-yl)-1H-indazol-6-yl]phenol trihydrobromide + 6-cyano-nicotinoyl chloride (313350-44-6) → C29H24FN7O2 (1421502-78-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

upstream raw materials:

6-cyanonicotinic acid

Nicotinic acid N-oxide

Downstream raw materials:

5-isocyanatopicolinonitrile

C₂₉H₂₄FN₇O₂

C₂₈H₂₂FN₇O₂

Refernces

• 1、 -. "INDAZOLES". Page/Page column 82. . Retrieved 2013/03/26.
• 2、 -. "Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators". Page 37. . Retrieved 2010/02/08.