1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone hydrate

Base Information

• Chemical Name: 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone hydrate
• CAS No.: 873205-85-7
• Molecular Formula: C₂₄H₂₁F₂NO₃*H₂O
• Molecular Weight: 427.448
• Mol file: 873205-85-7.mol

Synonyms:1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone hydrate

Chemical Property of 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone hydrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone hydrate

There total 2 articles about 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone hydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.5%

ezetemibe (163222-33-1,1478664-18-4,1593543-00-0,1593543-07-7,1478664-02-6) → 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone hydrate (873205-85-7)

Guidance literature:

With water; In methanol; at 0 - 20 ℃; for 0.5h; Product distribution / selectivity; Heating / reflux;

Reference yield: 74.5%

→ 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone hydrate (873205-85-7)

Guidance literature:

In water; tert-butyl alcohol; at 20 ℃; Purification / work up; Heating / reflux;

Reference yield: 99.0%

1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone hydrate (873205-85-7) → ezetemibe (163222-33-1,1478664-18-4,1593543-00-0,1593543-07-7,1478664-02-6)

Guidance literature:

In n-heptane; tert-butyl methyl ether; at 20 ℃; Product distribution / selectivity; Heating / reflux;

upstream raw materials:

ezetemibe

Downstream raw materials:

ezetemibe

Refernces