bortezomib pinacol ester

Base Information

• Chemical Name: bortezomib pinacol ester
• CAS No.: 1029701-48-1
• Molecular Formula: C₂₅H₃₅BN₄O₄
• Molecular Weight: 466.388
• Mol file: 1029701-48-1.mol

Synonyms:bortezomib pinacol ester

Chemical Property of bortezomib pinacol ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bortezomib pinacol ester

There total 12 articles about bortezomib pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(R)-3-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butan-1-amine hydrochloride + (S)-3-phenyl-2[(pyrazine-2-carbonyl)-amino]propionic acid (114457-94-2,1608986-16-8) → bortezomib pinacol ester (1029701-48-1)

Guidance literature:

With 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate; triethylamine; In dichloromethane; ethyl acetate; at 0 - 20 ℃; for 12h; Large scale;

Reference yield: 86.0%

C11H24BNO2*C2HF3O2 + (S)-3-phenyl-2[(pyrazine-2-carbonyl)-amino]propionic acid (114457-94-2,1608986-16-8) → bortezomib pinacol ester (1029701-48-1)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene; at 0 - 80 ℃; for 8h; Large scale;

Reference yield:

2-pyrazylcarboxylic acid (98-97-5) + (CH3)2CHCH2CH(BO2C2(CH3)4)NHCOCH(CH2C6H5)NH3(1+)*Cl(1-)=(CH3)2CHCH2CH(BO2C2(CH3)4)NHCOCH(CH2C6H5)NH3Cl (1029701-41-4) → bortezomib pinacol ester (1029701-48-1)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/ja800829y

upstream raw materials:

2-pyrazylcarboxylic acid

(CH₃)2CHCH₂CH(BO₂C₂(CH₃)4)NHCOCH(CH₂C₆H₅)NH₃⁽¹⁺⁾*Cl^(1-)=(CH₃)2CHCH₂CH(BO₂C₂(CH₃)4)NHCOCH(CH₂C₆H₅)NH₃Cl

(S)-3-phenyl-2[(pyrazine-2-carbonyl)-amino]propionic acid

bis(pinacol)diborane

Downstream raw materials:

velcade

Refernces

• 1、 Hinkes, Stefan P.A.,Klein, Christian D.P.. "Virtues of Volatility: A Facile Transesterification Approach to Boronic Acids". supporting information. p. 3048 - 3052. Retrieved 2019/05/10.
• 2、 -. "Method for preparing chiral amino acid ester and the boron for assists meters with the application in the synthesis of". Paragraph 0125; 0130; 0131. . Retrieved 2019/02/02.