6-METHOXY-PYRIDINE-3-SULFONYL CHLORIDE

Base Information

• Chemical Name: 6-METHOXY-PYRIDINE-3-SULFONYL CHLORIDE
• CAS No.: 312300-42-8
• Molecular Formula: C6H6ClNO3S
• Molecular Weight: 207.638
• Hs Code.: 2933399090
• Mol file: 312300-42-8.mol

Synonyms:6-Methoxypyridine-3-sulfonylchloride;6-Methoxypyridine-3-sulphonyl chloride;

Chemical Property of 6-METHOXY-PYRIDINE-3-SULFONYL CHLORIDE

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.534
• Boiling Point: 320.433 °C at 760 mmHg
• PKA: -3.56±0.11(Predicted)
• Flash Point: 147.593 °C
• PSA: 64.64000
• Density: 1.449 g/cm³
• LogP: 2.09850
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Methoxypyridine-3-sulfonylChloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36-43
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Methoxypyridine-3-sulfonyl Chloride is used in the synthesis of pharmaceuticals. It is used as a reactant in the preparation of sulfonate analogs of combretastatin A-4 as potent antimitotic agents. Also used in the preparation of compounds with H+,K+-ATPase inhibitory action and gastric acid secretion inhibitory activities.

Technology Process of 6-METHOXY-PYRIDINE-3-SULFONYL CHLORIDE

There total 4 articles about 6-METHOXY-PYRIDINE-3-SULFONYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

6-methoxy-pyridin-3-ylamine (6628-77-9) → 6-methoxypyridin-3-ylsulfonyl chloride (312300-42-8)

Guidance literature:

6-methoxy-pyridin-3-ylamine; With hydrogenchloride; sodium nitrite; In water; acetic acid; at 0 ℃;

With sulfur dioxide; copper dichloride; In water; acetic acid; at -20 - 20 ℃;

Reference yield:

2-amino-5-methoxypyridine (10167-97-2) → 6-methoxypyridin-3-ylsulfonyl chloride (312300-42-8)

Guidance literature:

2-amino-5-methoxypyridine; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.916667h;

With thionyl chloride; copper(l) chloride; In water; at 0 ℃; for 2.83333h;

Reference yield:

2-methoxy-5-bromopyridine (13472-85-0,1199266-76-6) → 6-methoxypyridin-3-ylsulfonyl chloride (312300-42-8)

Guidance literature:

2-methoxy-5-bromopyridine; With n-butyllithium; dibutylmagnesium; In tetrahydrofuran; at -10 ℃; Inert atmosphere;

With sulfuryl dichloride; In tetrahydrofuran; toluene; at -10 - 10 ℃;

DOI:10.1055/s-0030-1259953

upstream raw materials:

6-methoxy-pyridin-3-ylamine

2-methoxy-5-bromopyridine

2-amino-5-methoxypyridine

Downstream raw materials:

6-methoxypyridine-3-sulfonamide

sodium 6-methoxypyridine-3-sulfinate

Refernces

• 1、 -. "NEW SELECTIVE MODULATORS OF INSECT NICOTINIC ACETYLCHOLINE RECEPTORS". Page/Page column 18. . Retrieved 2020/06/01.
• 2、 Emura, Takashi,Yoshino, Hitoshi,Tachibana, Kazutaka,Shiraishi, Takuya,Honma, Akie,Mizutani, Akemi,Muraoka, Terushige. "Efficient and scalable synthesis of pyridine sulfonamides". experimental part. p. 1117 - 1120. Retrieved 2011/06/20.