1-Fluoro-3-iodopropane

Base Information

• Chemical Name: 1-Fluoro-3-iodopropane
• CAS No.: 462-40-8
• Molecular Formula: C3H6 F I
• Molecular Weight: 187.984
• Hs Code.: 2903799090
• European Community (EC) Number: 695-693-5
• Nikkaji Number: J532.418A
• Mol file: 462-40-8.mol

Synonyms:1-fluoro-3-iodopropane

Chemical Property of 1-Fluoro-3-iodopropane

Chemical Property:

• Refractive Index: 1.4955
• Boiling Point: 128.2°Cat760mmHg
• Flash Point: 33.8°C
• PSA: 0.00000
• Density: 1.837g/cm³
• LogP: 1.78100
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: Chloroform (Sparingly), Methanol (Slightly)
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 187.94983
• Heavy Atom Count: 5
• Complexity: 16.4

Purity/Quality:

99.9% ^*data from raw suppliers

1-Iodo-3-fluoropropane ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CF)CI
• Uses: 1-Iodo-3-fluoropropane could be a useful reagent for preparation as a radioligand for positron emission tomography imaging of cannabinoid receptors.

Technology Process of 1-Fluoro-3-iodopropane

There total 3 articles about 1-Fluoro-3-iodopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1-iodopropan-3-ol (627-32-7) → 1-fluoro-3-iodo-propane (462-40-8)

Guidance literature:

With diethylamino-sulfur trifluoride; In various solvent(s); at 0 ℃; for 2h;

DOI:10.1021/jm00167a031

Reference yield:

3-fluoropropane-1-ol (462-43-1) → 1-fluoro-3-iodo-propane (462-40-8)

Guidance literature:

With phosphorus; iodine;

DOI:10.1111/j.1365-2621.2001.tb11339.x

Reference yield:

1-Bromo-3-fluoropropane (352-91-0) → 1-fluoro-3-iodo-propane (462-40-8)

Guidance literature:

With acetone; sodium iodide;

DOI:10.1111/j.1365-2621.2001.tb11339.x

upstream raw materials:

3-fluoropropane-1-ol

1-Bromo-3-fluoropropane

1-iodopropan-3-ol

Downstream raw materials:

3-fluoro-1-nitropropane

3-hydroxy-4,5α-epoxy-6-methoxy-7α-(1-hydroxy-1-methylethyl)-6,14-endo-ethano-17-(3-fluoropropyl)morphinan

C₂₀H₂₀FNO₃

3-(4-(dimethylamino)phenyl)-6-(3-fluoropropoxy)-2H-chromen-2-one

Refernces