3-Piperidinecarboxamide,N,N-dimethyl-,(3S)-(9CI)

Base Information

• Chemical Name: 3-Piperidinecarboxamide,N,N-dimethyl-,(3S)-(9CI)
• CAS No.: 310455-02-8
• Molecular Formula: C8H16 N2 O
• Molecular Weight: 156.23
• Hs Code.: 2933399090
• Mol file: 310455-02-8.mol

Synonyms:(S)-N,N-Dimethyl-3-piperidinecarboxamide

Chemical Property of 3-Piperidinecarboxamide,N,N-dimethyl-,(3S)-(9CI)

Chemical Property:

• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.47
• Boiling Point: 269.095°C at 760 mmHg
• PKA: 9.43±0.10(Predicted)
• Flash Point: 116.545°C
• PSA: 32.34000
• Density: 0.992g/cm³
• LogP: 0.40300
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(S)-N,N-Dimethylpiperidine-3-carboxamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Piperidinecarboxamide,N,N-dimethyl-,(3S)-(9CI)

There total 3 articles about 3-Piperidinecarboxamide,N,N-dimethyl-,(3S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(4-tert-butyl-2-oxo-oxazolidin-3-yl)-N,N-dimethyl-nicotinamide (852872-33-4) → (R)-N,N-dimethylpiperidine-3-carboxamide + (S)-N,N-dimethyl-3-piperidinecarboxamide (310455-02-8)

Guidance literature:

With hydrogen; acetic acid; palladium dihydroxide; at 45 ℃; for 22h; under 75006 Torr; Title compound not separated from byproducts;

DOI:10.1002/anie.200453942

Reference yield:

(S)-N,N-dimethyl-3-piperidinecarboxamide-L-(dibenzoyl)tartrate salt (310455-03-9) → (S)-N,N-dimethyl-3-piperidinecarboxamide (310455-02-8)

Guidance literature:

With sodium hydroxide; In dichloromethane; water;

Reference yield:

→ (S)-N,N-dimethyl-3-piperidinecarboxamide (310455-02-8)

Guidance literature:

upstream raw materials:

6-(4-tert-butyl-2-oxo-oxazolidin-3-yl)-N,N-dimethyl-nicotinamide

(S)-N,N-dimethyl-3-piperidinecarboxamide-L-(dibenzoyl)tartrate salt

Downstream raw materials:

(S)-N,N-dimethyl-1-benzyl-3-piperidinecarboxamide

Refernces

• 1、 -. "Process for resolving racemic mixtures of piperidine derivatives". . . Retrieved 2008/06/13.